Chronic granulocytic leukemia

Recent information on pathogenesis, diagnosis, and disease monitoring

Ayalew Tefferi, Mark R Litzow, Pierre Noel, Gordon W. Dewald

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Current evidence strongly implicates the chromosome translocation t(9;22)(q34;q11.2) as the cause of chronic granulocytic leukemia. Therefore, identification of this genetic abnormality through either cytogenetic or molecular methods has become a requirement for diagnosis. Intense investigation of the mechanism by which t(9;22) transforms normal hematopoietic progenitors into malignant cells is ongoing. Recent advances in molecular diagnostic methods have allowed refined qualitative and quantitative methods of detecting t(9;22), which are useful for monitoring response status and detecting minimal residual disease. The current understanding of the pathogenesis of chronic granulocytic leukemia and the application of new diagnostic methods are discussed.

Original languageEnglish (US)
Pages (from-to)445-452
Number of pages8
JournalMayo Clinic Proceedings
Volume72
Issue number5
StatePublished - 1997

Fingerprint

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Molecular Pathology
Residual Neoplasm
Cytogenetics
Chromosomes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Chronic granulocytic leukemia : Recent information on pathogenesis, diagnosis, and disease monitoring. / Tefferi, Ayalew; Litzow, Mark R; Noel, Pierre; Dewald, Gordon W.

In: Mayo Clinic Proceedings, Vol. 72, No. 5, 1997, p. 445-452.

Research output: Contribution to journalArticle

@article{90765d781e73436487b490b210c3b45a,
title = "Chronic granulocytic leukemia: Recent information on pathogenesis, diagnosis, and disease monitoring",
abstract = "Current evidence strongly implicates the chromosome translocation t(9;22)(q34;q11.2) as the cause of chronic granulocytic leukemia. Therefore, identification of this genetic abnormality through either cytogenetic or molecular methods has become a requirement for diagnosis. Intense investigation of the mechanism by which t(9;22) transforms normal hematopoietic progenitors into malignant cells is ongoing. Recent advances in molecular diagnostic methods have allowed refined qualitative and quantitative methods of detecting t(9;22), which are useful for monitoring response status and detecting minimal residual disease. The current understanding of the pathogenesis of chronic granulocytic leukemia and the application of new diagnostic methods are discussed.",
author = "Ayalew Tefferi and Litzow, {Mark R} and Pierre Noel and Dewald, {Gordon W.}",
year = "1997",
language = "English (US)",
volume = "72",
pages = "445--452",
journal = "Mayo Clinic Proceedings",
issn = "0025-6196",
publisher = "Elsevier Science",
number = "5",

}

TY - JOUR

T1 - Chronic granulocytic leukemia

T2 - Recent information on pathogenesis, diagnosis, and disease monitoring

AU - Tefferi, Ayalew

AU - Litzow, Mark R

AU - Noel, Pierre

AU - Dewald, Gordon W.

PY - 1997

Y1 - 1997

N2 - Current evidence strongly implicates the chromosome translocation t(9;22)(q34;q11.2) as the cause of chronic granulocytic leukemia. Therefore, identification of this genetic abnormality through either cytogenetic or molecular methods has become a requirement for diagnosis. Intense investigation of the mechanism by which t(9;22) transforms normal hematopoietic progenitors into malignant cells is ongoing. Recent advances in molecular diagnostic methods have allowed refined qualitative and quantitative methods of detecting t(9;22), which are useful for monitoring response status and detecting minimal residual disease. The current understanding of the pathogenesis of chronic granulocytic leukemia and the application of new diagnostic methods are discussed.

AB - Current evidence strongly implicates the chromosome translocation t(9;22)(q34;q11.2) as the cause of chronic granulocytic leukemia. Therefore, identification of this genetic abnormality through either cytogenetic or molecular methods has become a requirement for diagnosis. Intense investigation of the mechanism by which t(9;22) transforms normal hematopoietic progenitors into malignant cells is ongoing. Recent advances in molecular diagnostic methods have allowed refined qualitative and quantitative methods of detecting t(9;22), which are useful for monitoring response status and detecting minimal residual disease. The current understanding of the pathogenesis of chronic granulocytic leukemia and the application of new diagnostic methods are discussed.

UR - http://www.scopus.com/inward/record.url?scp=0030947692&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030947692&partnerID=8YFLogxK

M3 - Article

VL - 72

SP - 445

EP - 452

JO - Mayo Clinic Proceedings

JF - Mayo Clinic Proceedings

SN - 0025-6196

IS - 5

ER -