Chronic glucocorticoid treatment alters spontaneous pulsatile parathyroid hormone secretory dynamics in human subjects

Stefania Bonadonna, Anna Burattin, Monica Nuzzo, Giovanna Bugari, Enrico Agabiti Rosei, Domenico Valle, Nicoletta Iori, John P. Bilezikian, Johannes D Veldhuis, Andrea Giustina

Research output: Contribution to journalArticle

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Abstract

Objective: Spontaneous parathyroid hormone (PTH) secretory dynamics include tonic and pulsatile components. It is not known how glucocorticoids might alter these secretory dynamics. Design: The aim of our study was to evaluate spontaneous fluctuations in serum PTH levels in six adult male patients (aged 31-64 years) receiving chronic ( > 6 months) therapy with glucocorticoids (daily dosage > 7.5 mg of prednisone or dose equivalent of other corticosteroid) as compared with a control group of 10 age- and sex-matched normal subjects. Methods: Peripheral venous blood sampling was performed every 3 min for 6 h from 0900 to 1500 h. Plasma PTH release profiles were subjected to deconvolution analysis, a method that resolves measured hormone concentrations into secretion and clearance components, and to an approximate entropy (ApEn) estimate, that in turn provides an integrated measure of the serial regularity or orderliness of the release process. Results: In the glucocorticoid-treated group, the PTH tonic secretory rate was reduced (4.3±0.74 vs 8.8±1.4 pg/ml per min in controls, P = 0.017). There was, however, an increase in the fractional pulsatile PTH secretion (42±8.2 vs 18.3±3.9 pg/ml per min, P = 0.006) in glucocorticoid-treated vs normal subjects. Mean overall PTH concentration, as well as mean integrated area, was similar among normal and glucocorticoid-treated subjects. Conclusions: These results demonstrate, for the first time, that chronic glucocorticoid treatment induces a redistribution of spontaneous PTH secretory dynamics by reducing the amount released in tonic fashion and increasing the amount released as pulses.

Original languageEnglish (US)
Pages (from-to)199-205
Number of pages7
JournalEuropean Journal of Endocrinology
Volume152
Issue number2
DOIs
StatePublished - Feb 2005

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Parathyroid Hormone
Glucocorticoids
Therapeutics
Secretory Rate
Entropy
Prednisone
Adrenal Cortex Hormones
Hormones
Control Groups
Serum

ASJC Scopus subject areas

  • Endocrinology

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Chronic glucocorticoid treatment alters spontaneous pulsatile parathyroid hormone secretory dynamics in human subjects. / Bonadonna, Stefania; Burattin, Anna; Nuzzo, Monica; Bugari, Giovanna; Rosei, Enrico Agabiti; Valle, Domenico; Iori, Nicoletta; Bilezikian, John P.; Veldhuis, Johannes D; Giustina, Andrea.

In: European Journal of Endocrinology, Vol. 152, No. 2, 02.2005, p. 199-205.

Research output: Contribution to journalArticle

Bonadonna, S, Burattin, A, Nuzzo, M, Bugari, G, Rosei, EA, Valle, D, Iori, N, Bilezikian, JP, Veldhuis, JD & Giustina, A 2005, 'Chronic glucocorticoid treatment alters spontaneous pulsatile parathyroid hormone secretory dynamics in human subjects', European Journal of Endocrinology, vol. 152, no. 2, pp. 199-205. https://doi.org/10.1530/eje.1.01841
Bonadonna, Stefania ; Burattin, Anna ; Nuzzo, Monica ; Bugari, Giovanna ; Rosei, Enrico Agabiti ; Valle, Domenico ; Iori, Nicoletta ; Bilezikian, John P. ; Veldhuis, Johannes D ; Giustina, Andrea. / Chronic glucocorticoid treatment alters spontaneous pulsatile parathyroid hormone secretory dynamics in human subjects. In: European Journal of Endocrinology. 2005 ; Vol. 152, No. 2. pp. 199-205.
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abstract = "Objective: Spontaneous parathyroid hormone (PTH) secretory dynamics include tonic and pulsatile components. It is not known how glucocorticoids might alter these secretory dynamics. Design: The aim of our study was to evaluate spontaneous fluctuations in serum PTH levels in six adult male patients (aged 31-64 years) receiving chronic ( > 6 months) therapy with glucocorticoids (daily dosage > 7.5 mg of prednisone or dose equivalent of other corticosteroid) as compared with a control group of 10 age- and sex-matched normal subjects. Methods: Peripheral venous blood sampling was performed every 3 min for 6 h from 0900 to 1500 h. Plasma PTH release profiles were subjected to deconvolution analysis, a method that resolves measured hormone concentrations into secretion and clearance components, and to an approximate entropy (ApEn) estimate, that in turn provides an integrated measure of the serial regularity or orderliness of the release process. Results: In the glucocorticoid-treated group, the PTH tonic secretory rate was reduced (4.3±0.74 vs 8.8±1.4 pg/ml per min in controls, P = 0.017). There was, however, an increase in the fractional pulsatile PTH secretion (42±8.2 vs 18.3±3.9 pg/ml per min, P = 0.006) in glucocorticoid-treated vs normal subjects. Mean overall PTH concentration, as well as mean integrated area, was similar among normal and glucocorticoid-treated subjects. Conclusions: These results demonstrate, for the first time, that chronic glucocorticoid treatment induces a redistribution of spontaneous PTH secretory dynamics by reducing the amount released in tonic fashion and increasing the amount released as pulses.",
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AU - Rosei, Enrico Agabiti

AU - Valle, Domenico

AU - Iori, Nicoletta

AU - Bilezikian, John P.

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