Chronic ethanol treatment increases the circulating plasma levels of b-type natriuretic peptide (Bnp-45) in the rat

D. A. Wigle; S. C. Pang; J. D. Watson; N. N. Radakovic; T. G. Flynn; I. R. Sarda

doi:10.1093/ajh/6.8.719

Chronic ethanol treatment increases the circulating plasma levels of b-type natriuretic peptide (Bnp-45) in the rat

D. A. Wigle, S. C. Pang, J. D. Watson, N. N. Radakovic, T. G. Flynn, I. R. Sarda

General Thoracic Surgery

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Abstract

Chronic ethanol ingestion is associated with a number of cardiovascular disorders, including stroke, heart failure, and hypertension. Given that the regulation of A-type natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) is known to be altered in both congestive heart failure and essential hypertension, we have investigated the regulation of BNP under the influence of ethanol ingestion. Sprague-Dawley rats were given ethanol in drinking fluid for a 6-week period, while a weight-matched liquid-restricted group received an equivalent volume of ethanol-free solution. Plasma BNP levels were increased in ethanol-treated animals relative to both liquid-restricted and normal control groups. No changes in cardiac BNP gene expression were observed, but an increased trend in atrial tissue BNP levels was evident. No changes in either the mRNA, tissue, or plasma levels of ANP were evident. These results suggest a differential regulation of natriuretic peptides under the influence of ethanol, and implicate chronic ethanol ingestion as a further clinical condition under which the plasma levels of a natriuretic peptide may be elevated. Am J Hypertens 1993;6:719-722.

Original language	English (US)
Pages (from-to)	719-722
Number of pages	4
Journal	American journal of hypertension
Volume	6
Issue number	8
DOIs	https://doi.org/10.1093/ajh/6.8.719
State	Published - Aug 1993

Keywords

A- and B-type natriuretic peptide
Alcoholism
Chronic ethanol ingestion

ASJC Scopus subject areas

Internal Medicine

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10.1093/ajh/6.8.719

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title = "Chronic ethanol treatment increases the circulating plasma levels of b-type natriuretic peptide (Bnp-45) in the rat",

abstract = "Chronic ethanol ingestion is associated with a number of cardiovascular disorders, including stroke, heart failure, and hypertension. Given that the regulation of A-type natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) is known to be altered in both congestive heart failure and essential hypertension, we have investigated the regulation of BNP under the influence of ethanol ingestion. Sprague-Dawley rats were given ethanol in drinking fluid for a 6-week period, while a weight-matched liquid-restricted group received an equivalent volume of ethanol-free solution. Plasma BNP levels were increased in ethanol-treated animals relative to both liquid-restricted and normal control groups. No changes in cardiac BNP gene expression were observed, but an increased trend in atrial tissue BNP levels was evident. No changes in either the mRNA, tissue, or plasma levels of ANP were evident. These results suggest a differential regulation of natriuretic peptides under the influence of ethanol, and implicate chronic ethanol ingestion as a further clinical condition under which the plasma levels of a natriuretic peptide may be elevated. Am J Hypertens 1993;6:719-722.",

keywords = "A- and B-type natriuretic peptide, Alcoholism, Chronic ethanol ingestion",

author = "Wigle, {D. A.} and Pang, {S. C.} and Watson, {J. D.} and Radakovic, {N. N.} and Flynn, {T. G.} and Sarda, {I. R.}",

note = "Funding Information: The authors wish to thank Kim Munro for his technical assistance, and Shirin Abdollah and Dr. Jim Brien for their assistance with gas chromatographic determinations of blood ethanol concentration. This work was supported by grants from the Medical Research Council of Canada and Queen's University of Kingston.",

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T1 - Chronic ethanol treatment increases the circulating plasma levels of b-type natriuretic peptide (Bnp-45) in the rat

AU - Wigle, D. A.

AU - Pang, S. C.

AU - Watson, J. D.

AU - Radakovic, N. N.

AU - Flynn, T. G.

AU - Sarda, I. R.

N1 - Funding Information: The authors wish to thank Kim Munro for his technical assistance, and Shirin Abdollah and Dr. Jim Brien for their assistance with gas chromatographic determinations of blood ethanol concentration. This work was supported by grants from the Medical Research Council of Canada and Queen's University of Kingston.

PY - 1993/8

Y1 - 1993/8

N2 - Chronic ethanol ingestion is associated with a number of cardiovascular disorders, including stroke, heart failure, and hypertension. Given that the regulation of A-type natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) is known to be altered in both congestive heart failure and essential hypertension, we have investigated the regulation of BNP under the influence of ethanol ingestion. Sprague-Dawley rats were given ethanol in drinking fluid for a 6-week period, while a weight-matched liquid-restricted group received an equivalent volume of ethanol-free solution. Plasma BNP levels were increased in ethanol-treated animals relative to both liquid-restricted and normal control groups. No changes in cardiac BNP gene expression were observed, but an increased trend in atrial tissue BNP levels was evident. No changes in either the mRNA, tissue, or plasma levels of ANP were evident. These results suggest a differential regulation of natriuretic peptides under the influence of ethanol, and implicate chronic ethanol ingestion as a further clinical condition under which the plasma levels of a natriuretic peptide may be elevated. Am J Hypertens 1993;6:719-722.

AB - Chronic ethanol ingestion is associated with a number of cardiovascular disorders, including stroke, heart failure, and hypertension. Given that the regulation of A-type natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) is known to be altered in both congestive heart failure and essential hypertension, we have investigated the regulation of BNP under the influence of ethanol ingestion. Sprague-Dawley rats were given ethanol in drinking fluid for a 6-week period, while a weight-matched liquid-restricted group received an equivalent volume of ethanol-free solution. Plasma BNP levels were increased in ethanol-treated animals relative to both liquid-restricted and normal control groups. No changes in cardiac BNP gene expression were observed, but an increased trend in atrial tissue BNP levels was evident. No changes in either the mRNA, tissue, or plasma levels of ANP were evident. These results suggest a differential regulation of natriuretic peptides under the influence of ethanol, and implicate chronic ethanol ingestion as a further clinical condition under which the plasma levels of a natriuretic peptide may be elevated. Am J Hypertens 1993;6:719-722.

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Chronic ethanol treatment increases the circulating plasma levels of b-type natriuretic peptide (Bnp-45) in the rat

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