Chronic electrical stimulation of the left ventrointermediate (Vim) thalamic nucleus for the treatment of pharmacotherapy-resistant Parkinson's disease: A differential impact on access to semantic and episodic memory?

Alexander I. Tröster, Steven B. Wilkinson, Julie A Fields, Karen Miyawaki, William C. Koller

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Thalamotomy for medically refractory Parkinson's disease (PD) is considered to be efficacious and relatively safe. Because a minority of patients experience decrements in language and memory (often mild and transient) after thalamotomy, chronic thalamic deep brain stimulation (DBS) might be a safer treatment given its reversibility and the modifiability of stimulation parameters. Two preliminary studies support the relative cognitive safety of unilateral DBS of the ventral intermediate (Vim) thalamic nucleus, but it is unclear whether possibly subtle changes in language and memory represent effects of 'microthalamotomy' or of stimulation per se. This report provides preliminary data concerning effects of left thalamic stimulation on information processing speed, semantic memory (verbal fluency and visual confrontation naming), and verbal episodic memory in a patient with PD. In addition to being evaluated before and 3 and 6 months after surgery, the patient was tested 18 months after surgery either on or off medications and with the stimulator turned either on or off (order counterbalanced across medication conditions). Test performance differences between the stimulation conditions were attenuated 'off' as compared to 'on' medication. Vim stimulation consistently, albeit subtly, improved semantic verbal fluency but interfered with immediate recall of word lists. Parallels to findings from acute, intraoperative thalamic stimulation studies are explored. The hypothesis is offered that is offered that left Vim stimulation might facilitate access to semantic memory, but interfere with episodic memory processes.

Original languageEnglish (US)
Pages (from-to)125-149
Number of pages25
JournalBrain and Cognition
Volume38
Issue number2
DOIs
StatePublished - Nov 1998
Externally publishedYes

Fingerprint

Thalamic Nuclei
Episodic Memory
Semantics
Electric Stimulation
Parkinson Disease
Drug Therapy
Deep Brain Stimulation
Language
Ventral Thalamic Nuclei
Therapeutics
Automatic Data Processing
Short-Term Memory
Safety
Stimulation
Parkinson's Disease
Nucleus
Pharmacotherapy
Semantic Memory

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Experimental and Cognitive Psychology
  • Neuropsychology and Physiological Psychology

Cite this

Chronic electrical stimulation of the left ventrointermediate (Vim) thalamic nucleus for the treatment of pharmacotherapy-resistant Parkinson's disease : A differential impact on access to semantic and episodic memory? / Tröster, Alexander I.; Wilkinson, Steven B.; Fields, Julie A; Miyawaki, Karen; Koller, William C.

In: Brain and Cognition, Vol. 38, No. 2, 11.1998, p. 125-149.

Research output: Contribution to journalArticle

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