Chronic effects of mechanical force on airways

Daniel J Tschumperlin, Jeffrey M. Drazen

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

Airways are embedded in the mechanically dynamic environment of the lung. In utero, this mechanical environment is defined largely by fluid secretion into the developing airway lumen. Clinical, whole lung, and cellular studies demonstrate pivotal roles for mechanical distention in airway morphogenesis and cellular behavior during lung development. In the adult lung, the mechanical environment is defined by a dynamic balance of surface, tissue, and muscle forces. Diseases of the airways modulate both the mechanical stresses to which the airways are exposed as well as the structure and mechanical behavior of the airways. For instance, in asthma, activation of airway smooth muscle abruptly changes the airway size and stress state within the airway wall; asthma also results in profound remodeling of the airway wall. Data now demonstrate that airway epithelial cells, smooth muscle cells, and fibroblasts respond to their mechanical environment. A prominent role has been identified for the epithelium in transducing mechanical stresses, and in both the fetal and mature airways, epithelial cells interact with mesenchymal cells to coordinate remodeling of tissue architecture in response to the mechanical environment.

Original languageEnglish (US)
Pages (from-to)563-583
Number of pages21
JournalAnnual Review of Physiology
Volume68
DOIs
StatePublished - 2006
Externally publishedYes

Fingerprint

Lung
Mechanical Stress
Asthma
Epithelial Cells
Airway Remodeling
Fluids and Secretions
Morphogenesis
Smooth Muscle Myocytes
Smooth Muscle
Epithelium
Fibroblasts
Muscles

Keywords

  • Airway remodeling
  • Epithelium
  • Mechanotransduction
  • Morphogenesis
  • Smooth muscle

ASJC Scopus subject areas

  • Physiology

Cite this

Chronic effects of mechanical force on airways. / Tschumperlin, Daniel J; Drazen, Jeffrey M.

In: Annual Review of Physiology, Vol. 68, 2006, p. 563-583.

Research output: Contribution to journalArticle

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