Chronic Cardiovascular Disease-Associated Gene Network Analysis in Human Umbilical Vein Endothelial Cells Exposed to 2,3,7,8-Tetrachlorodibenzo-p-dioxin

Medicine & Life Sciences

• Polychlorinated Dibenzodioxins 85%
• Gene Regulatory Networks 72%
• Human Umbilical Vein Endothelial Cells 71%
• Chronic Disease 49%
• Cardiovascular Diseases 48%
• Pulmonary Arterial Hypertension 26%
• Atherosclerosis 18%
• Adrenergic Receptors 14%
• Gene Expression 13%
• Endothelin-Converting Enzymes 11%
• Thromboangiitis Obliterans 11%
• STAT5 Transcription Factor 10%
• Myocardial Infarction 10%
• Dioxins 9%
• Hypertension 9%
• Genes 9%
• Platelet-Derived Growth Factor 8%
• Vascular System Injuries 8%
• Endothelin-1 8%
• Muscle Contraction 7%
• Vascular Smooth Muscle 7%
• Cardiovascular System 7%
• Interleukin-1beta 7%
• Epidemiologic Studies 6%
• Protein Isoforms 6%
• Thrombosis 5%
• Endothelial Cells 5%
• Tumor Necrosis Factor-alpha 5%
• Blood Pressure 4%
• Apoptosis 4%
• Morbidity 4%
• Mortality 3%

Chemical Compounds

• Endothelin-1 100%
• Blood Pressure 84%
• Collagen 63%