Chronic active autoimmune hepatitis in children. Strong association with a particular HLA-DR6 (DRB1*1301) haplotype

Leonardo Fainboim, Yanina Marcos, Marcelo Pando, Mónica Capucchio, Gloria B. Reyes, Cristina Galoppo, Isabel Badía, Graciela Remondino, Mirta Ciocca, Margarita Ramonet, Hugo Fainboim, M. Leonardo Satz

Research output: Contribution to journalArticlepeer-review

98 Scopus citations

Abstract

The association of HLA antigens and type I or "lupoid" CAH-C was investigated in a population of 52 Argentinian Caucasoid patients. When compared with a population of normal individuals of the same ethnic group (n = 197), a significant increase of HLA-DR6 was observed (68.6% in patients vs 17.3% in controls; RR = 12.3, χ2 = 52.4, pc = 0.00001). DNA typing showed that the HLA-DRB1*1301 allele was present in 32 out of 33 HLA-DR6 patients (66.6% of all the C-CAH patients vs 10.5% in controls; RR = 16.2, χ2 = 111.3, pc = 0.00001). Analysis of HLA-DQB1 alleles also showed a significant increase of DQB1*0603 (RR = 15.4, χ2 = 106.5, pc = 0.00001), an allele found in strong linkage disequilibrium with DRB1*1301. The association of CAH-C with this particular HLA-DR6 haplotype has not been previously described for the adult onset CAH. This different HLA predisposition, together with the fact that extrahepatic autoimmune diseases occur frequently only in the adult form of the disease, suggest that the immunopathogenic mechanisms involved in the development of these diseases may be different.

Original languageEnglish (US)
Pages (from-to)146-150
Number of pages5
JournalHuman Immunology
Volume41
Issue number2
DOIs
StatePublished - Oct 1994

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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