Chronic active autoimmune hepatitis in children. Strong association with a particular HLA-DR6 (DRB1*1301) haplotype

Leonardo Fainboim; Yanina Marcos; Marcelo Pando; Mónica Capucchio; Gloria B. Reyes; Cristina Galoppo; Isabel Badía; Graciela Remondino; Mirta Ciocca; Margarita Ramonet; Hugo Fainboim; M. Leonardo Satz

doi:10.1016/0198-8859(94)90008-6

Chronic active autoimmune hepatitis in children. Strong association with a particular HLA-DR6 (DRB1^*1301) haplotype

Leonardo Fainboim, Yanina Marcos, Marcelo Pando, Mónica Capucchio, Gloria B. Reyes, Cristina Galoppo, Isabel Badía, Graciela Remondino, Mirta Ciocca, Margarita Ramonet, Hugo Fainboim, M. Leonardo Satz

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

98 Scopus citations

Abstract

The association of HLA antigens and type I or "lupoid" CAH-C was investigated in a population of 52 Argentinian Caucasoid patients. When compared with a population of normal individuals of the same ethnic group (n = 197), a significant increase of HLA-DR6 was observed (68.6% in patients vs 17.3% in controls; RR = 12.3, χ² = 52.4, p_c = 0.00001). DNA typing showed that the HLA-DRB1^*1301 allele was present in 32 out of 33 HLA-DR6 patients (66.6% of all the C-CAH patients vs 10.5% in controls; RR = 16.2, χ² = 111.3, p_c = 0.00001). Analysis of HLA-DQB1 alleles also showed a significant increase of DQB1^*0603 (RR = 15.4, χ² = 106.5, p_c = 0.00001), an allele found in strong linkage disequilibrium with DRB1^*1301. The association of CAH-C with this particular HLA-DR6 haplotype has not been previously described for the adult onset CAH. This different HLA predisposition, together with the fact that extrahepatic autoimmune diseases occur frequently only in the adult form of the disease, suggest that the immunopathogenic mechanisms involved in the development of these diseases may be different.

Original language	English (US)
Pages (from-to)	146-150
Number of pages	5
Journal	Human Immunology
Volume	41
Issue number	2
DOIs	https://doi.org/10.1016/0198-8859(94)90008-6
State	Published - Oct 1994

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/0198-8859(94)90008-6

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@article{8010aa3b9efe4c3dadb39cbaf7e4c489,

title = "Chronic active autoimmune hepatitis in children. Strong association with a particular HLA-DR6 (DRB1*1301) haplotype",

abstract = "The association of HLA antigens and type I or {"}lupoid{"} CAH-C was investigated in a population of 52 Argentinian Caucasoid patients. When compared with a population of normal individuals of the same ethnic group (n = 197), a significant increase of HLA-DR6 was observed (68.6% in patients vs 17.3% in controls; RR = 12.3, χ2 = 52.4, pc = 0.00001). DNA typing showed that the HLA-DRB1*1301 allele was present in 32 out of 33 HLA-DR6 patients (66.6% of all the C-CAH patients vs 10.5% in controls; RR = 16.2, χ2 = 111.3, pc = 0.00001). Analysis of HLA-DQB1 alleles also showed a significant increase of DQB1*0603 (RR = 15.4, χ2 = 106.5, pc = 0.00001), an allele found in strong linkage disequilibrium with DRB1*1301. The association of CAH-C with this particular HLA-DR6 haplotype has not been previously described for the adult onset CAH. This different HLA predisposition, together with the fact that extrahepatic autoimmune diseases occur frequently only in the adult form of the disease, suggest that the immunopathogenic mechanisms involved in the development of these diseases may be different.",

author = "Leonardo Fainboim and Yanina Marcos and Marcelo Pando and M{\'o}nica Capucchio and Reyes, {Gloria B.} and Cristina Galoppo and Isabel Bad{\'i}a and Graciela Remondino and Mirta Ciocca and Margarita Ramonet and Hugo Fainboim and {Leonardo Satz}, M.",

note = "Funding Information: This work was supported in part by a Biotechnology Career Fellowship Grant from the Rockefeller Foundation to M. L. Satz and by grants from Fundacidn Antorchas, Fundacidn Roem-mers, and the University of Buenos Aires. We thank A. Baker for his assistance with the statistical analyses. L.F. and M.L.S. are members of the research Career of CONICET (Argentina). We also thank Drs. Dinah Singer, Elliot Cowan, and William Biddison for critical reading of the manuscript.",

year = "1994",

month = oct,

doi = "10.1016/0198-8859(94)90008-6",

language = "English (US)",

volume = "41",

pages = "146--150",

journal = "Human Immunology",

issn = "0198-8859",

publisher = "Elsevier Inc.",

number = "2",

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TY - JOUR

T1 - Chronic active autoimmune hepatitis in children. Strong association with a particular HLA-DR6 (DRB1*1301) haplotype

AU - Fainboim, Leonardo

AU - Marcos, Yanina

AU - Pando, Marcelo

AU - Capucchio, Mónica

AU - Reyes, Gloria B.

AU - Galoppo, Cristina

AU - Badía, Isabel

AU - Remondino, Graciela

AU - Ciocca, Mirta

AU - Ramonet, Margarita

AU - Fainboim, Hugo

AU - Leonardo Satz, M.

N1 - Funding Information: This work was supported in part by a Biotechnology Career Fellowship Grant from the Rockefeller Foundation to M. L. Satz and by grants from Fundacidn Antorchas, Fundacidn Roem-mers, and the University of Buenos Aires. We thank A. Baker for his assistance with the statistical analyses. L.F. and M.L.S. are members of the research Career of CONICET (Argentina). We also thank Drs. Dinah Singer, Elliot Cowan, and William Biddison for critical reading of the manuscript.

PY - 1994/10

Y1 - 1994/10

N2 - The association of HLA antigens and type I or "lupoid" CAH-C was investigated in a population of 52 Argentinian Caucasoid patients. When compared with a population of normal individuals of the same ethnic group (n = 197), a significant increase of HLA-DR6 was observed (68.6% in patients vs 17.3% in controls; RR = 12.3, χ2 = 52.4, pc = 0.00001). DNA typing showed that the HLA-DRB1*1301 allele was present in 32 out of 33 HLA-DR6 patients (66.6% of all the C-CAH patients vs 10.5% in controls; RR = 16.2, χ2 = 111.3, pc = 0.00001). Analysis of HLA-DQB1 alleles also showed a significant increase of DQB1*0603 (RR = 15.4, χ2 = 106.5, pc = 0.00001), an allele found in strong linkage disequilibrium with DRB1*1301. The association of CAH-C with this particular HLA-DR6 haplotype has not been previously described for the adult onset CAH. This different HLA predisposition, together with the fact that extrahepatic autoimmune diseases occur frequently only in the adult form of the disease, suggest that the immunopathogenic mechanisms involved in the development of these diseases may be different.

AB - The association of HLA antigens and type I or "lupoid" CAH-C was investigated in a population of 52 Argentinian Caucasoid patients. When compared with a population of normal individuals of the same ethnic group (n = 197), a significant increase of HLA-DR6 was observed (68.6% in patients vs 17.3% in controls; RR = 12.3, χ2 = 52.4, pc = 0.00001). DNA typing showed that the HLA-DRB1*1301 allele was present in 32 out of 33 HLA-DR6 patients (66.6% of all the C-CAH patients vs 10.5% in controls; RR = 16.2, χ2 = 111.3, pc = 0.00001). Analysis of HLA-DQB1 alleles also showed a significant increase of DQB1*0603 (RR = 15.4, χ2 = 106.5, pc = 0.00001), an allele found in strong linkage disequilibrium with DRB1*1301. The association of CAH-C with this particular HLA-DR6 haplotype has not been previously described for the adult onset CAH. This different HLA predisposition, together with the fact that extrahepatic autoimmune diseases occur frequently only in the adult form of the disease, suggest that the immunopathogenic mechanisms involved in the development of these diseases may be different.

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AN - SCOPUS:0028125280

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VL - 41

SP - 146

EP - 150

JO - Human Immunology

JF - Human Immunology

IS - 2

ER -

Chronic active autoimmune hepatitis in children. Strong association with a particular HLA-DR6 (DRB1^*1301) haplotype

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