Chromosomes in multiple endocrine neoplasia type 2 syndromes

D. L. Van Dyke, V. Ramesh Babu, C. E. Jackson

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4 Scopus citations

Abstract

In 19 patients from nine MEN-2A families, high-resolution G-banded chromosome studies have revealed a visible deletion within sub-band 20p12.2, yet no abnormality was observed in a 10th family. A deletion indistinguishable from that in MEN-2A was observed in five patients from three MEN-2B families but not in two other MEN-2B families. We found no abnormality in the entire karyotype of the four MEN-1 patients studied. These findings suggest that the mutation in most MEN-2 patients is a visible deletion in the short arm of chromosome 20.

Original languageEnglish (US)
Pages (from-to)266-268
Number of pages3
JournalHenry Ford Hospital Medical Journal
Volume32
Issue number4
StatePublished - 1984
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine(all)

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Van Dyke, D. L., Ramesh Babu, V., & Jackson, C. E. (1984). Chromosomes in multiple endocrine neoplasia type 2 syndromes. Henry Ford Hospital Medical Journal, 32(4), 266-268.