Chromosomes at Work: Organization of Chromosome Territories in the Interphase Nucleus

Andrew J. Fritz, A. Rasim Barutcu, Lori Martin-Buley, Andre J van Wijnen, Sayyed K. Zaidi, Anthony N. Imbalzano, Jane B. Lian, Janet L. Stein, Gary S. Stein

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

The organization of interphase chromosomes in chromosome territories (CTs) was first proposed more than one hundred years ago. The introduction of increasingly sophisticated microscopic and molecular techniques, now provide complementary strategies for studying CTs in greater depth than ever before. Here we provide an overview of these strategies and how they are being used to elucidate CT interactions and the role of these dynamically regulated, nuclear-structure building blocks in directly supporting nuclear function in a physiologically responsive manner.

Original languageEnglish (US)
Pages (from-to)9-19
Number of pages11
JournalJournal of Cellular Biochemistry
Volume117
Issue number1
DOIs
StatePublished - Jan 1 2016

Keywords

  • CTs
  • INTERPHASE
  • NUCLEUS

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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    Fritz, A. J., Barutcu, A. R., Martin-Buley, L., van Wijnen, A. J., Zaidi, S. K., Imbalzano, A. N., Lian, J. B., Stein, J. L., & Stein, G. S. (2016). Chromosomes at Work: Organization of Chromosome Territories in the Interphase Nucleus. Journal of Cellular Biochemistry, 117(1), 9-19. https://doi.org/10.1002/jcb.25280