Chromosome-centric human proteome project (C-HPP): Chromosome 12

Sakdithep Chaiyarit, Nilubon Singhto, Yi Ju Chen, Chia Ying Cheng, Wararat Chiangjong, Rattiyaporn Kanlaya, Henry H.N. Lam, Paleerath Peerapen, Ting Yi Sung, Phornpimon Tipthara, Akhilesh Pandey, Terence C.W. Poon, Yu Ju Chen, Ravi Sirdeshmukh, Maxey C.M. Chung, Visith Thongboonkerd

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Following an official announcement of the Chromosome-centric Human Proteome Project (C-HPP), the Chromosome 12 (Ch12) Consortium has been established by five representative teams from five Asian countries including Thailand (Siriraj Hospital, Mahidol University), Singapore (National University of Singapore), Taiwan (Academia Sinica), Hong Kong (The Chinese University of Hong Kong), and India (Institute of Bioinformatics). We have worked closely together to extensively and systematically analyze all missing and known proteins encoded by Ch12 for their tissue/cellular/subcellular localizations. The target organs/tissues/cells include kidney, brain, gastrointestinal tissues, blood/immune cells, and stem cells. In the later phase, post-translational modifications and functional significance of Ch12-encoded proteins as well as their associations with human diseases (i.e., immune diseases, metabolic disorders, and cancers) will be defined. We have collaborated with other chromosome teams, Human Kidney and Urine Proteome Project (HKUPP), AOHUPO Membrane Proteomics Initiative, and other existing HUPO initiatives in the Biology/Disease-Based Human Proteome Project (B/D-HPP) to delineate functional roles and medical implications of Ch12-encoded proteins. The data set to be obtained from this multicountry consortium will be an important piece of the jigsaw puzzle to fulfill the missions and goals of the C-HPP and the global Human Proteome Project (HPP).

Original languageEnglish (US)
Pages (from-to)3160-3165
Number of pages6
JournalJournal of Proteome Research
Volume13
Issue number7
DOIs
StatePublished - Jul 3 2014

Keywords

  • B/D-HPP
  • C-HPP
  • HPP
  • HUPO
  • Human Proteome Organization
  • Human Proteome Project
  • chromosome 12
  • chromosome-centric

ASJC Scopus subject areas

  • Biochemistry
  • Chemistry(all)

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    Chaiyarit, S., Singhto, N., Chen, Y. J., Cheng, C. Y., Chiangjong, W., Kanlaya, R., Lam, H. H. N., Peerapen, P., Sung, T. Y., Tipthara, P., Pandey, A., Poon, T. C. W., Chen, Y. J., Sirdeshmukh, R., Chung, M. C. M., & Thongboonkerd, V. (2014). Chromosome-centric human proteome project (C-HPP): Chromosome 12. Journal of Proteome Research, 13(7), 3160-3165. https://doi.org/10.1021/pr500009j