Chromosome 1 abnormalities in myeloid malignancies: A literature survey and karyotype-phenotype associations

Domenica Caramazza, Kebede Hussein, Sergio Siragusa, Animesh Pardanani, Ryan A. Knudson, Rhett P. Ketterling, Ayalew Tefferi

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

Chromosome 1 is the largest human chromosome and contains over 1600 known genes and 1000 novel coding sequences or transcripts. It is, therefore, not surprising that recurrent chromosome 1 abnormalities are regularly encountered in both neoplastic and non-neoplastic medical conditions. The current review is focused on myeloid malignancies where we summarize the relevant published literature and discuss specific karyotype-phenotype associations. We show that chromosome 1 abnormalities are most frequent in BCR-ABL-negative classic myeloproliferative neoplasms (MPN): polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). Specific abnormalities include duplications (e.g. 1q12→1q32 in PV, 1q21-32→1q32-44 in post-PV MF or PMF), deletions (e.g. 1p13-36→pter in PV or PMF, 1q21 in PMF) and unbalanced translocations involving chromosome 6, such as der(6)t(1;6)(q21- 25;p21.3-23), and other partner chromosomes involving 1q10/1p11 and 1q21-25 breakpoints. Although occasionally seen in chronic phase MPN, unbalanced 1;7 translocations, e.g. der(1;7)(q10;p10), are usually seen in acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), and post-MPN AML/MDS. These observations suggest that certain chromosome 1 regions, especially 1q21-1q32 and 1p11-13, might harbor oncogenes or tumor suppressor genes that are pathogenetically relevant to both chronic and advanced phases of MPN.

Original languageEnglish (US)
Pages (from-to)191-200
Number of pages10
JournalEuropean Journal of Haematology
Volume84
Issue number3
DOIs
StatePublished - Mar 1 2010

    Fingerprint

Keywords

  • Chromosome 1
  • Cytogenetic
  • Karyotype
  • Myelofibrosis
  • Myeloid
  • Myeloproliferative

ASJC Scopus subject areas

  • Hematology

Cite this