Chromosome 1 abnormalities in myeloid malignancies: A literature survey and karyotype-phenotype associations

Domenica Caramazza, Kebede Hussein, Sergio Siragusa, Animesh D Pardanani, Ryan A. Knudson, Rhett P. Ketterling, Ayalew Tefferi

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Chromosome 1 is the largest human chromosome and contains over 1600 known genes and 1000 novel coding sequences or transcripts. It is, therefore, not surprising that recurrent chromosome 1 abnormalities are regularly encountered in both neoplastic and non-neoplastic medical conditions. The current review is focused on myeloid malignancies where we summarize the relevant published literature and discuss specific karyotype-phenotype associations. We show that chromosome 1 abnormalities are most frequent in BCR-ABL-negative classic myeloproliferative neoplasms (MPN): polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). Specific abnormalities include duplications (e.g. 1q12→1q32 in PV, 1q21-32→1q32-44 in post-PV MF or PMF), deletions (e.g. 1p13-36→pter in PV or PMF, 1q21 in PMF) and unbalanced translocations involving chromosome 6, such as der(6)t(1;6)(q21- 25;p21.3-23), and other partner chromosomes involving 1q10/1p11 and 1q21-25 breakpoints. Although occasionally seen in chronic phase MPN, unbalanced 1;7 translocations, e.g. der(1;7)(q10;p10), are usually seen in acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), and post-MPN AML/MDS. These observations suggest that certain chromosome 1 regions, especially 1q21-1q32 and 1p11-13, might harbor oncogenes or tumor suppressor genes that are pathogenetically relevant to both chronic and advanced phases of MPN.

Original languageEnglish (US)
Pages (from-to)191-200
Number of pages10
JournalEuropean Journal of Haematology
Volume84
Issue number3
DOIs
StatePublished - Mar 2010

Fingerprint

Chromosomes, Human, Pair 1
Polycythemia Vera
Karyotype
Primary Myelofibrosis
Chromosome Aberrations
Phenotype
Myelodysplastic Syndromes
Neoplasms
Acute Myeloid Leukemia
Essential Thrombocythemia
Chromosomes, Human, Pair 6
Human Chromosomes
Tumor Suppressor Genes
Oncogenes
Chromosomes
Surveys and Questionnaires
Genes

Keywords

  • Chromosome 1
  • Cytogenetic
  • Karyotype
  • Myelofibrosis
  • Myeloid
  • Myeloproliferative

ASJC Scopus subject areas

  • Hematology

Cite this

Chromosome 1 abnormalities in myeloid malignancies : A literature survey and karyotype-phenotype associations. / Caramazza, Domenica; Hussein, Kebede; Siragusa, Sergio; Pardanani, Animesh D; Knudson, Ryan A.; Ketterling, Rhett P.; Tefferi, Ayalew.

In: European Journal of Haematology, Vol. 84, No. 3, 03.2010, p. 191-200.

Research output: Contribution to journalArticle

Caramazza, Domenica ; Hussein, Kebede ; Siragusa, Sergio ; Pardanani, Animesh D ; Knudson, Ryan A. ; Ketterling, Rhett P. ; Tefferi, Ayalew. / Chromosome 1 abnormalities in myeloid malignancies : A literature survey and karyotype-phenotype associations. In: European Journal of Haematology. 2010 ; Vol. 84, No. 3. pp. 191-200.
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