Chromosomal Localization of the Mouse Src-like Adapter Protein (Slap) Gene and Its Putative Human Homolog SLA

Misha Angrist, Dan E. Wells, Aravinda Chakravarti, Akhilesh Pandey

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Molecules containing Src-homology 2 (SH2) and Src-homology 3 (SH3) domains are critical components of signal transduction pathways that serve to relay signals originating from the cell surface to the interior of the cell. Src-like adapter protein (SLAP) is a recently described adapter protein that binds activated the Eck receptor protein-tyrosine kinase. Although SLAP bears a striking homology to the SH3 and SH2 domains of the Src family of nonreceptor tyrosine kinases, it does not contain a tyrosine kinase catalytic domain. In this report, the Slap gene was mapped by linkage analysis to mouse chromosome 15, while its putative human homolog (SLA) was identified and mapped to human 8q22.3-qter using a panel of somatic cell hybrids.

Original languageEnglish (US)
Pages (from-to)623-625
Number of pages3
JournalGenomics
Volume30
Issue number3
DOIs
StatePublished - Dec 10 1995
Externally publishedYes

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src Homology Domains
Genes
Proteins
Chromosomes, Human, Pair 15
src-Family Kinases
Hybrid Cells
Receptor Protein-Tyrosine Kinases
Protein-Tyrosine Kinases
Signal Transduction
Catalytic Domain
Mouse Sla protein

ASJC Scopus subject areas

  • Genetics

Cite this

Chromosomal Localization of the Mouse Src-like Adapter Protein (Slap) Gene and Its Putative Human Homolog SLA. / Angrist, Misha; Wells, Dan E.; Chakravarti, Aravinda; Pandey, Akhilesh.

In: Genomics, Vol. 30, No. 3, 10.12.1995, p. 623-625.

Research output: Contribution to journalArticle

Angrist, Misha ; Wells, Dan E. ; Chakravarti, Aravinda ; Pandey, Akhilesh. / Chromosomal Localization of the Mouse Src-like Adapter Protein (Slap) Gene and Its Putative Human Homolog SLA. In: Genomics. 1995 ; Vol. 30, No. 3. pp. 623-625.
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