Chromosomal Localization of the Mouse Src-like Adapter Protein (Slap) Gene and Its Putative Human Homolog SLA

Misha Angrist, Dan E. Wells, Aravinda Chakravarti, Akhilesh Pandey

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Molecules containing Src-homology 2 (SH2) and Src-homology 3 (SH3) domains are critical components of signal transduction pathways that serve to relay signals originating from the cell surface to the interior of the cell. Src-like adapter protein (SLAP) is a recently described adapter protein that binds activated the Eck receptor protein-tyrosine kinase. Although SLAP bears a striking homology to the SH3 and SH2 domains of the Src family of nonreceptor tyrosine kinases, it does not contain a tyrosine kinase catalytic domain. In this report, the Slap gene was mapped by linkage analysis to mouse chromosome 15, while its putative human homolog (SLA) was identified and mapped to human 8q22.3-qter using a panel of somatic cell hybrids.

Original languageEnglish (US)
Pages (from-to)623-625
Number of pages3
JournalGenomics
Volume30
Issue number3
DOIs
StatePublished - Dec 10 1995

ASJC Scopus subject areas

  • Genetics

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