Chromophobe renal cell carcinoma

The impact of tumor grade on outcome

John C. Cheville, Christine M. Lohse, William R. Sukov, Robert Houston Thompson, Bradley C. Leibovich

Research output: Contribution to journalReview article

40 Citations (Scopus)

Abstract

It has been reported that Fuhrman grading is not appropriate for chromophobe renal cell carcinoma (RCC). The objective of this study was to determine whether nucleolar grading and the recently described chromophobe RCC grading system by Paner and colleagues provide prognostic information. Pathologic features of 185 patients with chromophobe RCC treated surgically between 1970 and 2006 were reviewed, including nucleolar grade, chromophobe RCC grade, the 2010 TNM groupings, sarcomatoid differentiation, and coagulative tumor necrosis. Cancer-specific (CS) survival was estimated using the Kaplan-Meier method, and associations with CS survival were evaluated using Cox proportional hazard regression models. Twenty-three patients died from RCC at a mean of 3.0 years after surgery (median 1.3; range 0 to 16) with estimated CS rates (95% confidence interval) of 89% (84 to 94), 86% (81 to 92), and 85% (78 to 91) at 5, 10, and 15 years after surgery. Univariate associations with CS survival included the 2010 TNM stage groupings, sarcomatoid differentiation, coagulative tumor necrosis, chromophobe RCC grade, and nucleolar grade (all P<0.001). These last 4 features remained significantly associated with CS survival after adjusting for the 2010 TNM stage groupings. When the analysis was restricted to the 155 patients with nonsarcomatoid TNM stage groupings I and II chromophobe RCC, only stage grouping (I vs. II) was significantly associated with CS survival (P=0.03). Although the chromophobe RCC grading system described by Paner and colleagues and nucleolar grade are associated with CS survival in chromophobe RCC, they add no additional prognostic information once TNM stage and sarcomatoid differentiation are assessed.

Original languageEnglish (US)
Pages (from-to)851-856
Number of pages6
JournalAmerican Journal of Surgical Pathology
Volume36
Issue number6
DOIs
StatePublished - Jun 2012

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Renal Cell Carcinoma
Neoplasms
Survival
Necrosis
Proportional Hazards Models
Confidence Intervals

Keywords

  • Chromophobe
  • Grade
  • Kidney
  • Outcome
  • Renal cell carcinoma

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery

Cite this

Cheville, J. C., Lohse, C. M., Sukov, W. R., Thompson, R. H., & Leibovich, B. C. (2012). Chromophobe renal cell carcinoma: The impact of tumor grade on outcome. American Journal of Surgical Pathology, 36(6), 851-856. https://doi.org/10.1097/PAS.0b013e3182496895

Chromophobe renal cell carcinoma : The impact of tumor grade on outcome. / Cheville, John C.; Lohse, Christine M.; Sukov, William R.; Thompson, Robert Houston; Leibovich, Bradley C.

In: American Journal of Surgical Pathology, Vol. 36, No. 6, 06.2012, p. 851-856.

Research output: Contribution to journalReview article

Cheville, JC, Lohse, CM, Sukov, WR, Thompson, RH & Leibovich, BC 2012, 'Chromophobe renal cell carcinoma: The impact of tumor grade on outcome', American Journal of Surgical Pathology, vol. 36, no. 6, pp. 851-856. https://doi.org/10.1097/PAS.0b013e3182496895
Cheville, John C. ; Lohse, Christine M. ; Sukov, William R. ; Thompson, Robert Houston ; Leibovich, Bradley C. / Chromophobe renal cell carcinoma : The impact of tumor grade on outcome. In: American Journal of Surgical Pathology. 2012 ; Vol. 36, No. 6. pp. 851-856.
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