Chromatin remodeling, histone modifications, and DNA methylation - How does it all fit together?

Theresa M. Geiman, Keith D Robertson

Research output: Contribution to journalArticle

219 Citations (Scopus)

Abstract

DNA methylation is important in the control of gene transcription and chromatin structure. The complexities of this process are just beginning to be elucidated in relationship to other epigenetic mechanisms. Exciting new research in the areas of histone methylation and chromatin remodeling make it clear just how important the connections between these various mechanisms and DNA methylation are for the control of chromosome structure and gene expression. Emerging evidence suggests that chromatin remodeling enzymes and histone methylation are essential for proper DNA methylation patterns. Other histone modifications, such as acetylation and phosphorylation, in turn, affect histone methylation and histone methylation also appears to be highly reliant on chromatin remodeling enzymes. This review will summarize what is likely only the beginning of a flood of new information that will ultimately link all epigenetic modifications of the mammalian genome. A model will also be put forth to account for how chromatin modifications lead to genomic DNA methylation patterns.

Original languageEnglish (US)
Pages (from-to)117-125
Number of pages9
JournalJournal of Cellular Biochemistry
Volume87
Issue number2
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Histone Code
Chromatin Assembly and Disassembly
DNA Methylation
Methylation
Histones
Chromatin
Epigenomics
Chromosome Structures
Genes
Enzymes
Acetylation
Phosphorylation
Transcription
Chromosomes
Gene expression
Genome
Gene Expression
Research

Keywords

  • Chromatin remodeling
  • DNA methylation
  • Epigenetics
  • Gene expression
  • Histone methylation

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

Chromatin remodeling, histone modifications, and DNA methylation - How does it all fit together? / Geiman, Theresa M.; Robertson, Keith D.

In: Journal of Cellular Biochemistry, Vol. 87, No. 2, 2002, p. 117-125.

Research output: Contribution to journalArticle

@article{22244f9023f4442cb262eaff4b835aea,
title = "Chromatin remodeling, histone modifications, and DNA methylation - How does it all fit together?",
abstract = "DNA methylation is important in the control of gene transcription and chromatin structure. The complexities of this process are just beginning to be elucidated in relationship to other epigenetic mechanisms. Exciting new research in the areas of histone methylation and chromatin remodeling make it clear just how important the connections between these various mechanisms and DNA methylation are for the control of chromosome structure and gene expression. Emerging evidence suggests that chromatin remodeling enzymes and histone methylation are essential for proper DNA methylation patterns. Other histone modifications, such as acetylation and phosphorylation, in turn, affect histone methylation and histone methylation also appears to be highly reliant on chromatin remodeling enzymes. This review will summarize what is likely only the beginning of a flood of new information that will ultimately link all epigenetic modifications of the mammalian genome. A model will also be put forth to account for how chromatin modifications lead to genomic DNA methylation patterns.",
keywords = "Chromatin remodeling, DNA methylation, Epigenetics, Gene expression, Histone methylation",
author = "Geiman, {Theresa M.} and Robertson, {Keith D}",
year = "2002",
doi = "10.1002/jcb.10286",
language = "English (US)",
volume = "87",
pages = "117--125",
journal = "Journal of Cellular Biochemistry",
issn = "0730-2312",
publisher = "Wiley-Liss Inc.",
number = "2",

}

TY - JOUR

T1 - Chromatin remodeling, histone modifications, and DNA methylation - How does it all fit together?

AU - Geiman, Theresa M.

AU - Robertson, Keith D

PY - 2002

Y1 - 2002

N2 - DNA methylation is important in the control of gene transcription and chromatin structure. The complexities of this process are just beginning to be elucidated in relationship to other epigenetic mechanisms. Exciting new research in the areas of histone methylation and chromatin remodeling make it clear just how important the connections between these various mechanisms and DNA methylation are for the control of chromosome structure and gene expression. Emerging evidence suggests that chromatin remodeling enzymes and histone methylation are essential for proper DNA methylation patterns. Other histone modifications, such as acetylation and phosphorylation, in turn, affect histone methylation and histone methylation also appears to be highly reliant on chromatin remodeling enzymes. This review will summarize what is likely only the beginning of a flood of new information that will ultimately link all epigenetic modifications of the mammalian genome. A model will also be put forth to account for how chromatin modifications lead to genomic DNA methylation patterns.

AB - DNA methylation is important in the control of gene transcription and chromatin structure. The complexities of this process are just beginning to be elucidated in relationship to other epigenetic mechanisms. Exciting new research in the areas of histone methylation and chromatin remodeling make it clear just how important the connections between these various mechanisms and DNA methylation are for the control of chromosome structure and gene expression. Emerging evidence suggests that chromatin remodeling enzymes and histone methylation are essential for proper DNA methylation patterns. Other histone modifications, such as acetylation and phosphorylation, in turn, affect histone methylation and histone methylation also appears to be highly reliant on chromatin remodeling enzymes. This review will summarize what is likely only the beginning of a flood of new information that will ultimately link all epigenetic modifications of the mammalian genome. A model will also be put forth to account for how chromatin modifications lead to genomic DNA methylation patterns.

KW - Chromatin remodeling

KW - DNA methylation

KW - Epigenetics

KW - Gene expression

KW - Histone methylation

UR - http://www.scopus.com/inward/record.url?scp=0036383067&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036383067&partnerID=8YFLogxK

U2 - 10.1002/jcb.10286

DO - 10.1002/jcb.10286

M3 - Article

C2 - 12244565

AN - SCOPUS:0036383067

VL - 87

SP - 117

EP - 125

JO - Journal of Cellular Biochemistry

JF - Journal of Cellular Biochemistry

SN - 0730-2312

IS - 2

ER -