TY - JOUR
T1 - Chromatin modifiers and histone modifications in bone formation, regeneration, and therapeutic intervention for bone-related disease
AU - Gordon, Jonathan A.R.
AU - Stein, Janet L.
AU - Westendorf, Jennifer J.
AU - Van Wijnen, Andre J.
N1 - Publisher Copyright:
© 2015 Elsevier Inc. All rights reserved.
PY - 2015/1/13
Y1 - 2015/1/13
N2 - Post-translational modifications of chromatin such as DNA methylation and different types of histone acetylation, methylation and phosphorylation are well-appreciated epigenetic mechanisms that confer information to progeny cells during lineage commitment. These distinct epigenetic modifications have defined roles in bone, development, tissue regeneration, cell commitment and differentiation, as well as disease etiologies. In this review, we discuss the role of these chromatin modifications and the enzymes regulating these marks (methyltransferases, demethylases, acetyltransferases, and deacetylases) in progenitor cells, osteoblasts and bone-related cells. In addition, the clinical relevance of deregulated histone modifications and enzymes as well as current and potential therapeutic interventions targeting chromatin modifiers are addressed.
AB - Post-translational modifications of chromatin such as DNA methylation and different types of histone acetylation, methylation and phosphorylation are well-appreciated epigenetic mechanisms that confer information to progeny cells during lineage commitment. These distinct epigenetic modifications have defined roles in bone, development, tissue regeneration, cell commitment and differentiation, as well as disease etiologies. In this review, we discuss the role of these chromatin modifications and the enzymes regulating these marks (methyltransferases, demethylases, acetyltransferases, and deacetylases) in progenitor cells, osteoblasts and bone-related cells. In addition, the clinical relevance of deregulated histone modifications and enzymes as well as current and potential therapeutic interventions targeting chromatin modifiers are addressed.
KW - Acetylation
KW - Chromatin
KW - Chromatin-modifiers
KW - Epigenetics
KW - Methylation
KW - Osteogenic lineage cells
UR - http://www.scopus.com/inward/record.url?scp=84955201306&partnerID=8YFLogxK
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U2 - 10.1016/j.bone.2015.03.011
DO - 10.1016/j.bone.2015.03.011
M3 - Review article
C2 - 25836763
AN - SCOPUS:84955201306
SN - 8756-3282
VL - 81
SP - 739
EP - 745
JO - Bone
JF - Bone
ER -