Chromatin modifiers and histone modifications in bone formation, regeneration, and therapeutic intervention for bone-related disease

Jonathan A.R. Gordon, Janet L. Stein, Jennifer J. Westendorf, Andre J. Van Wijnen

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations

Abstract

Post-translational modifications of chromatin such as DNA methylation and different types of histone acetylation, methylation and phosphorylation are well-appreciated epigenetic mechanisms that confer information to progeny cells during lineage commitment. These distinct epigenetic modifications have defined roles in bone, development, tissue regeneration, cell commitment and differentiation, as well as disease etiologies. In this review, we discuss the role of these chromatin modifications and the enzymes regulating these marks (methyltransferases, demethylases, acetyltransferases, and deacetylases) in progenitor cells, osteoblasts and bone-related cells. In addition, the clinical relevance of deregulated histone modifications and enzymes as well as current and potential therapeutic interventions targeting chromatin modifiers are addressed.

Original languageEnglish (US)
Pages (from-to)739-745
Number of pages7
JournalBone
Volume81
DOIs
StatePublished - Jan 13 2015

Keywords

  • Acetylation
  • Chromatin
  • Chromatin-modifiers
  • Epigenetics
  • Methylation
  • Osteogenic lineage cells

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Histology

Fingerprint Dive into the research topics of 'Chromatin modifiers and histone modifications in bone formation, regeneration, and therapeutic intervention for bone-related disease'. Together they form a unique fingerprint.

Cite this