Chromatin Dynamics and Epigenetics of Stem Cells and Stem-Like Cancer Cells

Alexandre Gaspar-Maia; Ana Sevilla

doi:10.1016/B978-0-12-802389-1.00017-4

Chromatin Dynamics and Epigenetics of Stem Cells and Stem-Like Cancer Cells

Alexandre Gaspar-Maia, Ana Sevilla

Laboratory Medicine and Pathology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Embryonic stem cells must be transformed into fate-restricted derivatives before being used for cell therapy. Discerning the intrinsic plasticity and regenerative potential of stem cell populations requires studying chromatin dynamic modifications that shape their respective epigenomes. Here, we review the epigenetic changes during stem cell commitment and highlight the processes deregulated in stem-like cancer cells. Detailed understanding of these molecular regulations will significantly contribute to our understanding of developmental process with utility for regenerative therapeutics.

Original language	English (US)
Title of host publication	Chromatin Signaling and Diseases
Publisher	Elsevier Inc.
Pages	311-327
Number of pages	17
ISBN (Electronic)	9780128026090
ISBN (Print)	9780128023891
DOIs	https://doi.org/10.1016/B978-0-12-802389-1.00017-4
State	Published - Aug 24 2016

Keywords

Cancer stem-like cells
Chromatin dynamics
Epigenome
Histone marks
Human embryonic stem cell

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/B978-0-12-802389-1.00017-4

Cite this

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N2 - Embryonic stem cells must be transformed into fate-restricted derivatives before being used for cell therapy. Discerning the intrinsic plasticity and regenerative potential of stem cell populations requires studying chromatin dynamic modifications that shape their respective epigenomes. Here, we review the epigenetic changes during stem cell commitment and highlight the processes deregulated in stem-like cancer cells. Detailed understanding of these molecular regulations will significantly contribute to our understanding of developmental process with utility for regenerative therapeutics.

AB - Embryonic stem cells must be transformed into fate-restricted derivatives before being used for cell therapy. Discerning the intrinsic plasticity and regenerative potential of stem cell populations requires studying chromatin dynamic modifications that shape their respective epigenomes. Here, we review the epigenetic changes during stem cell commitment and highlight the processes deregulated in stem-like cancer cells. Detailed understanding of these molecular regulations will significantly contribute to our understanding of developmental process with utility for regenerative therapeutics.

KW - Cancer stem-like cells

KW - Chromatin dynamics

KW - Epigenome

KW - Histone marks

KW - Human embryonic stem cell

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M3 - Chapter

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BT - Chromatin Signaling and Diseases

PB - Elsevier Inc.

ER -

Chromatin Dynamics and Epigenetics of Stem Cells and Stem-Like Cancer Cells

Abstract

Keywords

ASJC Scopus subject areas

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