Chromatin Dynamics and Epigenetics of Stem Cells and Stem-Like Cancer Cells

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Embryonic stem cells must be transformed into fate-restricted derivatives before being used for cell therapy. Discerning the intrinsic plasticity and regenerative potential of stem cell populations requires studying chromatin dynamic modifications that shape their respective epigenomes. Here, we review the epigenetic changes during stem cell commitment and highlight the processes deregulated in stem-like cancer cells. Detailed understanding of these molecular regulations will significantly contribute to our understanding of developmental process with utility for regenerative therapeutics.

Original languageEnglish (US)
Title of host publicationChromatin Signaling and Diseases
PublisherElsevier Inc.
Pages311-327
Number of pages17
ISBN (Electronic)9780128026090
ISBN (Print)9780128023891
DOIs
StatePublished - Aug 24 2016
Externally publishedYes

Keywords

  • Cancer stem-like cells
  • Chromatin dynamics
  • Epigenome
  • Histone marks
  • Human embryonic stem cell

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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