Chromatin

J. A.R. Gordon; R. A. Grandy; J. B. Lian; J. L. Stein; Andre J van Wijnen; G. S. Stein

doi:10.1016/B978-0-12-374984-0.00235-7

Chromatin

J. A.R. Gordon, R. A. Grandy, J. B. Lian, J. L. Stein, Andre J van Wijnen, G. S. Stein

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

Chromatin is a highly organized complex of DNA and proteins and is a principal component of the cell nucleus. Histone proteins help organize DNA into structural units called nucleosomes, which are then assembled into a compact structure (chromatin) and eventually into very large, high-order structures (chromosomes). The localized accessibility of chromatin is largely regulated by posttranslational modifications of both histone proteins and DNA, which have dramatic effects on the regulation of chromatin structure, binding of chromatin-modifying complexes, and transcriptional regulators. This article examines previously established and recently discovered roles of chromatin as a structural component of the nucleus and as a regulator of activation and repression of gene transcriptional activity.

Original language	English (US)
Title of host publication	Brenner's Encyclopedia of Genetics
Subtitle of host publication	Second Edition
Publisher	Elsevier Inc.
Pages	538-541
Number of pages	4
ISBN (Electronic)	9780080961569
ISBN (Print)	9780123749840
DOIs	https://doi.org/10.1016/B978-0-12-374984-0.00235-7
State	Published - Feb 27 2013
Externally published	Yes

Keywords

Chromatin
Chromosome
DNA
Epigenetics
Euchromatin
Heterochromatin
Histone modification
Histones
Nuclear matrix
Nucleosomes

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

Access to Document

10.1016/B978-0-12-374984-0.00235-7

Cite this

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title = "Chromatin",

abstract = "Chromatin is a highly organized complex of DNA and proteins and is a principal component of the cell nucleus. Histone proteins help organize DNA into structural units called nucleosomes, which are then assembled into a compact structure (chromatin) and eventually into very large, high-order structures (chromosomes). The localized accessibility of chromatin is largely regulated by posttranslational modifications of both histone proteins and DNA, which have dramatic effects on the regulation of chromatin structure, binding of chromatin-modifying complexes, and transcriptional regulators. This article examines previously established and recently discovered roles of chromatin as a structural component of the nucleus and as a regulator of activation and repression of gene transcriptional activity.",

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author = "Gordon, {J. A.R.} and Grandy, {R. A.} and Lian, {J. B.} and Stein, {J. L.} and {van Wijnen}, {Andre J} and Stein, {G. S.}",

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AU - Gordon, J. A.R.

AU - Grandy, R. A.

AU - Lian, J. B.

AU - Stein, J. L.

AU - van Wijnen, Andre J

AU - Stein, G. S.

PY - 2013/2/27

Y1 - 2013/2/27

N2 - Chromatin is a highly organized complex of DNA and proteins and is a principal component of the cell nucleus. Histone proteins help organize DNA into structural units called nucleosomes, which are then assembled into a compact structure (chromatin) and eventually into very large, high-order structures (chromosomes). The localized accessibility of chromatin is largely regulated by posttranslational modifications of both histone proteins and DNA, which have dramatic effects on the regulation of chromatin structure, binding of chromatin-modifying complexes, and transcriptional regulators. This article examines previously established and recently discovered roles of chromatin as a structural component of the nucleus and as a regulator of activation and repression of gene transcriptional activity.

AB - Chromatin is a highly organized complex of DNA and proteins and is a principal component of the cell nucleus. Histone proteins help organize DNA into structural units called nucleosomes, which are then assembled into a compact structure (chromatin) and eventually into very large, high-order structures (chromosomes). The localized accessibility of chromatin is largely regulated by posttranslational modifications of both histone proteins and DNA, which have dramatic effects on the regulation of chromatin structure, binding of chromatin-modifying complexes, and transcriptional regulators. This article examines previously established and recently discovered roles of chromatin as a structural component of the nucleus and as a regulator of activation and repression of gene transcriptional activity.

KW - Chromatin

KW - Chromosome

KW - DNA

KW - Epigenetics

KW - Euchromatin

KW - Heterochromatin

KW - Histone modification

KW - Histones

KW - Nuclear matrix

KW - Nucleosomes

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SN - 9780123749840

SP - 538

EP - 541

BT - Brenner's Encyclopedia of Genetics

PB - Elsevier Inc.

ER -

Chromatin

Abstract

Keywords

ASJC Scopus subject areas

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