Choristoma of the optic nerve: Case report

Caterina Giannini, Carol Reynolds, Jacqueline A. Leavitt, Gregory A. Schultz, James A. Garrity, Michael J. Ebersold, Bernd W. Scheithauer, Diva R. Salomao, Ghassan K. Bejjani, Kimberly C. Cockerham, John S. Kennerdell, William Rotfus, Joseph C. Maroon, Kalmon D. Post

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

OBJECTIVE AND IMPORTANCE: Optic nerve choristoma is a rare lesion composed of adipose tissue and smooth muscle involving the optic nerve. Few cases have been reported. CLINICAL PRESENTATION: A 20-year-old woman presented with a history of slowly progressive visual loss in the left eye. On T1-weighted magnetic resonance imaging studies, after frequency-selective fat saturation, an optic nerve mass was detected at the level of the optic canal with signal characteristics suggesting the diagnosis of optic nerve lipoma. INTERVENTION: At left frontotemporal craniotomy, the intracranial optic nerve appeared thin and atrophic proximally and was covered by abundant adipose tissue distally. Because no cleavage plane could be identified between the fatty lesion and the optic nerve, which appeared splayed within the adipose tissue, the nerve was resected after an intraoperative biopsy. The presence of two heterotopic mesodermal elements, a rim of adipose tissue admixed with bundles of mature smooth muscle, extending into the nerve septa, warranted a diagnosis of optic nerve choristoma. CONCLUSION: Optic nerve choristoma is an uncommon optic nerve lesion. Even if imaging studies are highly suggestive of the diagnosis, pathological confirmation is required because of the high adipose tissue content in the majority of cases. The lesion, most likely malformative and nonneoplastic in nature, can be the cause of progressive visual loss.

Original languageEnglish (US)
Pages (from-to)1125-1128
Number of pages4
JournalNeurosurgery
Volume50
Issue number5
DOIs
StatePublished - May 1 2002

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Choristoma
Optic Nerve
Adipose Tissue
Smooth Muscle
Lipoma
Craniotomy
Fats
Magnetic Resonance Imaging
Biopsy

Keywords

  • Choristoma
  • Lipoma
  • Neuroimaging
  • Optic nerve neoplasm

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Giannini, C., Reynolds, C., Leavitt, J. A., Schultz, G. A., Garrity, J. A., Ebersold, M. J., ... Post, K. D. (2002). Choristoma of the optic nerve: Case report. Neurosurgery, 50(5), 1125-1128. https://doi.org/10.1097/00006123-200205000-00032

Choristoma of the optic nerve : Case report. / Giannini, Caterina; Reynolds, Carol; Leavitt, Jacqueline A.; Schultz, Gregory A.; Garrity, James A.; Ebersold, Michael J.; Scheithauer, Bernd W.; Salomao, Diva R.; Bejjani, Ghassan K.; Cockerham, Kimberly C.; Kennerdell, John S.; Rotfus, William; Maroon, Joseph C.; Post, Kalmon D.

In: Neurosurgery, Vol. 50, No. 5, 01.05.2002, p. 1125-1128.

Research output: Contribution to journalArticle

Giannini, C, Reynolds, C, Leavitt, JA, Schultz, GA, Garrity, JA, Ebersold, MJ, Scheithauer, BW, Salomao, DR, Bejjani, GK, Cockerham, KC, Kennerdell, JS, Rotfus, W, Maroon, JC & Post, KD 2002, 'Choristoma of the optic nerve: Case report', Neurosurgery, vol. 50, no. 5, pp. 1125-1128. https://doi.org/10.1097/00006123-200205000-00032
Giannini C, Reynolds C, Leavitt JA, Schultz GA, Garrity JA, Ebersold MJ et al. Choristoma of the optic nerve: Case report. Neurosurgery. 2002 May 1;50(5):1125-1128. https://doi.org/10.1097/00006123-200205000-00032
Giannini, Caterina ; Reynolds, Carol ; Leavitt, Jacqueline A. ; Schultz, Gregory A. ; Garrity, James A. ; Ebersold, Michael J. ; Scheithauer, Bernd W. ; Salomao, Diva R. ; Bejjani, Ghassan K. ; Cockerham, Kimberly C. ; Kennerdell, John S. ; Rotfus, William ; Maroon, Joseph C. ; Post, Kalmon D. / Choristoma of the optic nerve : Case report. In: Neurosurgery. 2002 ; Vol. 50, No. 5. pp. 1125-1128.
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