Cholinesterases and the fine line between poison and remedy

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Acetylcholinesterase (AChE, EC 3.1.1.7) and butyrylcholinesterase (BChE, EC 3.1.1.8) are related enzymes found across the animal kingdom. The critical role of acetylcholinesterase in neurotransmission has been known for almost a century, but a physiological role for butyrylcholinesterase is just now emerging. The cholinesterases have been deliberately targeted for both therapy and toxicity, with cholinesterase inhibitors being used in the clinic for a variety of disorders and conversely for their toxic potential as pesticides and chemical weapons. Non-catalytic functions of the cholinesterases (ChEs) participate in both neurodevelopment and disease. Manipulating either the catalytic activities or the structure of these enzymes can potentially shift the balance between beneficial and adverse effect in a wide number of physiological processes.

Original languageEnglish (US)
JournalBiochemical Pharmacology
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Butyrylcholinesterase
Poisons
Cholinesterases
Acetylcholinesterase
Cholinesterase Inhibitors
Enzymes
Pesticides
Physiological Phenomena
Toxicity
Catalyst activity
Animals
Weapons
Synaptic Transmission
Therapeutics

Keywords

  • Acetylcholinesterase
  • Alzheimer's
  • Butyrylcholinesterase
  • Cholinergic signaling
  • Cholinesterase inhibitors
  • Ghrelin metabolism
  • Organophosphates

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology

Cite this

Cholinesterases and the fine line between poison and remedy. / Pope, Carey N.; Brimijoin, William Stephen.

In: Biochemical Pharmacology, 01.01.2018.

Research output: Contribution to journalArticle

@article{a9fb254f9de24dde88c289c9765a7298,
title = "Cholinesterases and the fine line between poison and remedy",
abstract = "Acetylcholinesterase (AChE, EC 3.1.1.7) and butyrylcholinesterase (BChE, EC 3.1.1.8) are related enzymes found across the animal kingdom. The critical role of acetylcholinesterase in neurotransmission has been known for almost a century, but a physiological role for butyrylcholinesterase is just now emerging. The cholinesterases have been deliberately targeted for both therapy and toxicity, with cholinesterase inhibitors being used in the clinic for a variety of disorders and conversely for their toxic potential as pesticides and chemical weapons. Non-catalytic functions of the cholinesterases (ChEs) participate in both neurodevelopment and disease. Manipulating either the catalytic activities or the structure of these enzymes can potentially shift the balance between beneficial and adverse effect in a wide number of physiological processes.",
keywords = "Acetylcholinesterase, Alzheimer's, Butyrylcholinesterase, Cholinergic signaling, Cholinesterase inhibitors, Ghrelin metabolism, Organophosphates",
author = "Pope, {Carey N.} and Brimijoin, {William Stephen}",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.bcp.2018.01.044",
language = "English (US)",
journal = "Biochemical Pharmacology",
issn = "0006-2952",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Cholinesterases and the fine line between poison and remedy

AU - Pope, Carey N.

AU - Brimijoin, William Stephen

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Acetylcholinesterase (AChE, EC 3.1.1.7) and butyrylcholinesterase (BChE, EC 3.1.1.8) are related enzymes found across the animal kingdom. The critical role of acetylcholinesterase in neurotransmission has been known for almost a century, but a physiological role for butyrylcholinesterase is just now emerging. The cholinesterases have been deliberately targeted for both therapy and toxicity, with cholinesterase inhibitors being used in the clinic for a variety of disorders and conversely for their toxic potential as pesticides and chemical weapons. Non-catalytic functions of the cholinesterases (ChEs) participate in both neurodevelopment and disease. Manipulating either the catalytic activities or the structure of these enzymes can potentially shift the balance between beneficial and adverse effect in a wide number of physiological processes.

AB - Acetylcholinesterase (AChE, EC 3.1.1.7) and butyrylcholinesterase (BChE, EC 3.1.1.8) are related enzymes found across the animal kingdom. The critical role of acetylcholinesterase in neurotransmission has been known for almost a century, but a physiological role for butyrylcholinesterase is just now emerging. The cholinesterases have been deliberately targeted for both therapy and toxicity, with cholinesterase inhibitors being used in the clinic for a variety of disorders and conversely for their toxic potential as pesticides and chemical weapons. Non-catalytic functions of the cholinesterases (ChEs) participate in both neurodevelopment and disease. Manipulating either the catalytic activities or the structure of these enzymes can potentially shift the balance between beneficial and adverse effect in a wide number of physiological processes.

KW - Acetylcholinesterase

KW - Alzheimer's

KW - Butyrylcholinesterase

KW - Cholinergic signaling

KW - Cholinesterase inhibitors

KW - Ghrelin metabolism

KW - Organophosphates

UR - http://www.scopus.com/inward/record.url?scp=85041731977&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85041731977&partnerID=8YFLogxK

U2 - 10.1016/j.bcp.2018.01.044

DO - 10.1016/j.bcp.2018.01.044

M3 - Article

C2 - 29409903

AN - SCOPUS:85041731977

JO - Biochemical Pharmacology

JF - Biochemical Pharmacology

SN - 0006-2952

ER -