Cholesterol Management in the Era of PCSK9 Inhibitors

Anna Svatikova, Stephen L. Kopecky

Research output: Contribution to journalReview articlepeer-review


Purpose of Review: Cholesterol management in the current era is discussed. Aggressive reduction of low density lipoprotein (LDL) cholesterol plays a key role in primary and secondary prevention of heart disease. Statins are the recommended first-line therapy in patients with hyperlipidemia; however, additional complementary approaches are frequently needed for patients who fail to reach their target LDL. Recent Findings: Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors are novel drugs that provide dramatic lowering of LDL and promise outcome benefit. Despite great enthusiasm about their cardiovascular benefit, concerns have been raised regarding their cost and added value to the healthcare system. Although cost-effectiveness studies have yielded inconclusive results, analyses suggest that the current cost of PCSK9 inhibitors is disproportionately high and must be significantly reduced to add positive net benefit to healthcare system. Summary: PCSK9 inhibitors significantly lower LDL cholesterol. Further outcome data and cost-effectiveness analyses are needed to overcome the current barriers with PCSK9 inhibitors that patients, physicians, and payers face.

Original languageEnglish (US)
Article number83
JournalCurrent cardiology reports
Issue number9
StatePublished - Sep 1 2017


  • Cardiovascular disease
  • Cholesterol
  • PCSK9 inhibitors
  • Prevention
  • Statins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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