Cholesterol crystal induced arterial inflammation and destabilization of atherosclerotic plaque

Abed Janoudi, Fadi E. Shamoun, Jagadeesh K. Kalavakunta, George S. Abela

Research output: Contribution to journalReview article

79 Scopus citations

Abstract

Evolution of plaque that is prone to rupture is characterized by inflammation and physical changes. Accumulation of low-density lipoprotein in the sub-intima provides esterified cholesterol (ESC) to macrophages and smooth muscle cells that convert it into free cholesterol (FRC) by cholesteryl ester hydrolases (CEHs). Membrane-bound cholesterol carriers transport FRC to high-density lipoprotein (HDL). Impaired HDL transport function and altered composition can lead to extracellular accumulation of FRC, whereas impaired membrane carrier activity can lead to intracellular FRC accumulation. Saturation of FRC can result in cholesterol crystallization with cell death and intimal injury. Disequilibrium between ESC and FRC can impact foam cell and cholesterol crystal (CC) formation. Cholesterol crystals initiate inflammation via NLRP3 inflammasome leading to interleukin-1β (IL-1β) production inducing C-reactive protein. Eventually, crystals growing from within the plaque and associated inflammation destabilize the plaque. Thus, inhibition of inflammation by antagonists to IL-1β or agents that dissolve or prevent CC formation may stabilize vulnerable plaques.

Original languageEnglish (US)
Pages (from-to)1959-1967
Number of pages9
JournalEuropean heart journal
Volume37
Issue number25
DOIs
StatePublished - Jul 1 2016

Keywords

  • Atherosclerosis
  • Cholesterol crystals
  • IL-1b
  • Vascular inflammation
  • Vulnerable patient
  • Vulnerable plaque

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Cholesterol crystal induced arterial inflammation and destabilization of atherosclerotic plaque'. Together they form a unique fingerprint.

  • Cite this