Cholecystokinin depolarizes neurons of cat pancreatic ganglion

R. C. Ma, J. H. Szurszewski

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The effect of cholecystokinin octapeptide (CCK-8) on membrane potential and conductance of cat pancreatic ganglion neurons was studied in vitro by means of intracellular microelectrode recording methods. Microejection of S-CCK-8 and NS-CCK-8 evoked, by direct action, a slow, reversible membrane depolarization. The majority of neurons tested were more sensitive to S-CCK-8. The depolarizing response to S-CCK-8 and NS-CCK-8 was accompanied in different neurons by a variable change in membrane permeability to Na+ and/or K+. The effects of S-CCK-8 and NS-CCK-8 were mediated by the CCK(B) receptor. The results suggest that S-CCK-8 and NS-CCK-8 increase the excitability of pancreatic ganglion neurons by acting on postsynaptic CCK(B) receptors.

Original languageEnglish (US)
Pages (from-to)775-783
Number of pages9
JournalPeptides
Volume17
Issue number5
DOIs
StatePublished - 1996

Fingerprint

Sincalide
Cholecystokinin
Ganglia
Neurons
Cats
Cholecystokinin B Receptor
Membranes
Microelectrodes
Depolarization
Membrane Potentials
Permeability
8-sulfocholecystokinin octapeptide

Keywords

  • Caerulein
  • Cat
  • Cholecystokinin
  • Gastrin
  • L-364,718
  • L-365,260
  • Membrane depolarization
  • Pancreas
  • Pancreatic ganglion neuron

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

Cholecystokinin depolarizes neurons of cat pancreatic ganglion. / Ma, R. C.; Szurszewski, J. H.

In: Peptides, Vol. 17, No. 5, 1996, p. 775-783.

Research output: Contribution to journalArticle

Ma, R. C. ; Szurszewski, J. H. / Cholecystokinin depolarizes neurons of cat pancreatic ganglion. In: Peptides. 1996 ; Vol. 17, No. 5. pp. 775-783.
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