Cholecystokinin depolarizes neurons of cat pancreatic ganglion

R. C. Ma, J. H. Szurszewski

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The effect of cholecystokinin octapeptide (CCK-8) on membrane potential and conductance of cat pancreatic ganglion neurons was studied in vitro by means of intracellular microelectrode recording methods. Microejection of S-CCK-8 and NS-CCK-8 evoked, by direct action, a slow, reversible membrane depolarization. The majority of neurons tested were more sensitive to S-CCK-8. The depolarizing response to S-CCK-8 and NS-CCK-8 was accompanied in different neurons by a variable change in membrane permeability to Na+ and/or K+. The effects of S-CCK-8 and NS-CCK-8 were mediated by the CCK(B) receptor. The results suggest that S-CCK-8 and NS-CCK-8 increase the excitability of pancreatic ganglion neurons by acting on postsynaptic CCK(B) receptors.

Original languageEnglish (US)
Pages (from-to)775-783
Number of pages9
JournalPeptides
Volume17
Issue number5
DOIs
StatePublished - Jan 1 1996

Keywords

  • Caerulein
  • Cat
  • Cholecystokinin
  • Gastrin
  • L-364,718
  • L-365,260
  • Membrane depolarization
  • Pancreas
  • Pancreatic ganglion neuron

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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