Cholecystectomy and the risk of colorectal cancer by tumor mismatch repair deficiency status

Jie Shang; Jeanette C. Reece; Daniel D. Buchanan; Graham G. Giles; Jane C. Figueiredo; Graham Casey; Steven Gallinger; Stephen N. Thibodeau; Noralane M. Lindor; Polly A. Newcomb; John D. Potter; John A. Baron; John L. Hopper; Mark A. Jenkins; Aung Ko Win

doi:10.1007/s00384-016-2615-5

Cholecystectomy and the risk of colorectal cancer by tumor mismatch repair deficiency status

Jie Shang, Jeanette C. Reece, Daniel D. Buchanan, Graham G. Giles, Jane C. Figueiredo, Graham Casey, Steven Gallinger, Stephen N. Thibodeau, Noralane M. Lindor, Polly A. Newcomb, John D. Potter, John A. Baron, John L. Hopper, Mark A. Jenkins, Aung Ko Win

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Purpose: Gallbladder diseases and cholecystectomy may play a role in the development of colorectal cancer (CRC). Our aim was to investigate the association between cholecystectomy and CRC risk overall and by sex, family history, anatomical location, and tumor mismatch repair (MMR) status. Methods: This study comprised 5847 incident CRC cases recruited from population cancer registries in Australia, Canada, and the USA into the Colon Cancer Family Registry between 1997 and 2012 and 4970 controls with no personal history of CRC who were either randomly selected from the general population or were spouses of the cases. The association between cholecystectomy and CRC was estimated using logistic regression, after adjusting for confounding factors. Results: Overall, there was no evidence for an association between cholecystectomy and CRC (odds ratio [OR] = 0.88, 95 % confidence interval 0.73, 1.08). In the stratified analyses, there was no evidence for a difference in the association between women and men (P = 0.54), between individuals with and without family history of CRC in first-degree relative (P = 0.64), between tumor anatomical locations (P = 0.45), or between MMR-proficient and MMR-deficient cases (P = 0.54). Conclusion: Cholecystectomy is not a substantial risk factor for CRC, regardless of sex, family history, anatomical location, or tumor MMR status.

Original language	English (US)
Pages (from-to)	1451-1457
Number of pages	7
Journal	International Journal of Colorectal Disease
Volume	31
Issue number	8
DOIs	https://doi.org/10.1007/s00384-016-2615-5
State	Published - Aug 1 2016

Keywords

Cholecystectomy
Colorectal cancer
Gallbladder
Mismatch repair

ASJC Scopus subject areas

Gastroenterology

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10.1007/s00384-016-2615-5

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Shang, J., Reece, J. C., Buchanan, D. D., Giles, G. G., Figueiredo, J. C., Casey, G., Gallinger, S., Thibodeau, S. N., Lindor, N. M., Newcomb, P. A., Potter, J. D., Baron, J. A., Hopper, J. L., Jenkins, M. A., & Win, A. K. (2016). Cholecystectomy and the risk of colorectal cancer by tumor mismatch repair deficiency status. International Journal of Colorectal Disease, 31(8), 1451-1457. https://doi.org/10.1007/s00384-016-2615-5

Cholecystectomy and the risk of colorectal cancer by tumor mismatch repair deficiency status. / Shang, Jie; Reece, Jeanette C.; Buchanan, Daniel D.; Giles, Graham G.; Figueiredo, Jane C.; Casey, Graham; Gallinger, Steven; Thibodeau, Stephen N.; Lindor, Noralane M.; Newcomb, Polly A.; Potter, John D.; Baron, John A.; Hopper, John L.; Jenkins, Mark A.; Win, Aung Ko.

In: International Journal of Colorectal Disease, Vol. 31, No. 8, 01.08.2016, p. 1451-1457.

Research output: Contribution to journal › Article › peer-review

Shang, J, Reece, JC, Buchanan, DD, Giles, GG, Figueiredo, JC, Casey, G, Gallinger, S, Thibodeau, SN, Lindor, NM, Newcomb, PA, Potter, JD, Baron, JA, Hopper, JL, Jenkins, MA & Win, AK 2016, 'Cholecystectomy and the risk of colorectal cancer by tumor mismatch repair deficiency status', International Journal of Colorectal Disease, vol. 31, no. 8, pp. 1451-1457. https://doi.org/10.1007/s00384-016-2615-5

Shang, Jie ; Reece, Jeanette C. ; Buchanan, Daniel D. ; Giles, Graham G. ; Figueiredo, Jane C. ; Casey, Graham ; Gallinger, Steven ; Thibodeau, Stephen N. ; Lindor, Noralane M. ; Newcomb, Polly A. ; Potter, John D. ; Baron, John A. ; Hopper, John L. ; Jenkins, Mark A. ; Win, Aung Ko. / Cholecystectomy and the risk of colorectal cancer by tumor mismatch repair deficiency status. In: International Journal of Colorectal Disease. 2016 ; Vol. 31, No. 8. pp. 1451-1457.

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abstract = "Purpose: Gallbladder diseases and cholecystectomy may play a role in the development of colorectal cancer (CRC). Our aim was to investigate the association between cholecystectomy and CRC risk overall and by sex, family history, anatomical location, and tumor mismatch repair (MMR) status. Methods: This study comprised 5847 incident CRC cases recruited from population cancer registries in Australia, Canada, and the USA into the Colon Cancer Family Registry between 1997 and 2012 and 4970 controls with no personal history of CRC who were either randomly selected from the general population or were spouses of the cases. The association between cholecystectomy and CRC was estimated using logistic regression, after adjusting for confounding factors. Results: Overall, there was no evidence for an association between cholecystectomy and CRC (odds ratio [OR] = 0.88, 95 % confidence interval 0.73, 1.08). In the stratified analyses, there was no evidence for a difference in the association between women and men (P = 0.54), between individuals with and without family history of CRC in first-degree relative (P = 0.64), between tumor anatomical locations (P = 0.45), or between MMR-proficient and MMR-deficient cases (P = 0.54). Conclusion: Cholecystectomy is not a substantial risk factor for CRC, regardless of sex, family history, anatomical location, or tumor MMR status.",

keywords = "Cholecystectomy, Colorectal cancer, Gallbladder, Mismatch repair",

author = "Jie Shang and Reece, {Jeanette C.} and Buchanan, {Daniel D.} and Giles, {Graham G.} and Figueiredo, {Jane C.} and Graham Casey and Steven Gallinger and Thibodeau, {Stephen N.} and Lindor, {Noralane M.} and Newcomb, {Polly A.} and Potter, {John D.} and Baron, {John A.} and Hopper, {John L.} and Jenkins, {Mark A.} and Win, {Aung Ko}",

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AU - Shang, Jie

AU - Reece, Jeanette C.

AU - Buchanan, Daniel D.

AU - Giles, Graham G.

AU - Figueiredo, Jane C.

AU - Casey, Graham

AU - Gallinger, Steven

AU - Thibodeau, Stephen N.

AU - Lindor, Noralane M.

AU - Newcomb, Polly A.

AU - Potter, John D.

AU - Baron, John A.

AU - Hopper, John L.

AU - Jenkins, Mark A.

AU - Win, Aung Ko

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N2 - Purpose: Gallbladder diseases and cholecystectomy may play a role in the development of colorectal cancer (CRC). Our aim was to investigate the association between cholecystectomy and CRC risk overall and by sex, family history, anatomical location, and tumor mismatch repair (MMR) status. Methods: This study comprised 5847 incident CRC cases recruited from population cancer registries in Australia, Canada, and the USA into the Colon Cancer Family Registry between 1997 and 2012 and 4970 controls with no personal history of CRC who were either randomly selected from the general population or were spouses of the cases. The association between cholecystectomy and CRC was estimated using logistic regression, after adjusting for confounding factors. Results: Overall, there was no evidence for an association between cholecystectomy and CRC (odds ratio [OR] = 0.88, 95 % confidence interval 0.73, 1.08). In the stratified analyses, there was no evidence for a difference in the association between women and men (P = 0.54), between individuals with and without family history of CRC in first-degree relative (P = 0.64), between tumor anatomical locations (P = 0.45), or between MMR-proficient and MMR-deficient cases (P = 0.54). Conclusion: Cholecystectomy is not a substantial risk factor for CRC, regardless of sex, family history, anatomical location, or tumor MMR status.

AB - Purpose: Gallbladder diseases and cholecystectomy may play a role in the development of colorectal cancer (CRC). Our aim was to investigate the association between cholecystectomy and CRC risk overall and by sex, family history, anatomical location, and tumor mismatch repair (MMR) status. Methods: This study comprised 5847 incident CRC cases recruited from population cancer registries in Australia, Canada, and the USA into the Colon Cancer Family Registry between 1997 and 2012 and 4970 controls with no personal history of CRC who were either randomly selected from the general population or were spouses of the cases. The association between cholecystectomy and CRC was estimated using logistic regression, after adjusting for confounding factors. Results: Overall, there was no evidence for an association between cholecystectomy and CRC (odds ratio [OR] = 0.88, 95 % confidence interval 0.73, 1.08). In the stratified analyses, there was no evidence for a difference in the association between women and men (P = 0.54), between individuals with and without family history of CRC in first-degree relative (P = 0.64), between tumor anatomical locations (P = 0.45), or between MMR-proficient and MMR-deficient cases (P = 0.54). Conclusion: Cholecystectomy is not a substantial risk factor for CRC, regardless of sex, family history, anatomical location, or tumor MMR status.

KW - Cholecystectomy

KW - Colorectal cancer

KW - Gallbladder

KW - Mismatch repair

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