Cholecystectomy and the risk of colorectal cancer by tumor mismatch repair deficiency status

Jie Shang, Jeanette C. Reece, Daniel D. Buchanan, Graham G. Giles, Jane C. Figueiredo, Graham Casey, Steven Gallinger, Stephen N Thibodeau, Noralane Morey Lindor, Polly A. Newcomb, John D. Potter, John A. Baron, John L. Hopper, Mark A. Jenkins, Aung Ko Win

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: Gallbladder diseases and cholecystectomy may play a role in the development of colorectal cancer (CRC). Our aim was to investigate the association between cholecystectomy and CRC risk overall and by sex, family history, anatomical location, and tumor mismatch repair (MMR) status. Methods: This study comprised 5847 incident CRC cases recruited from population cancer registries in Australia, Canada, and the USA into the Colon Cancer Family Registry between 1997 and 2012 and 4970 controls with no personal history of CRC who were either randomly selected from the general population or were spouses of the cases. The association between cholecystectomy and CRC was estimated using logistic regression, after adjusting for confounding factors. Results: Overall, there was no evidence for an association between cholecystectomy and CRC (odds ratio [OR] = 0.88, 95 % confidence interval 0.73, 1.08). In the stratified analyses, there was no evidence for a difference in the association between women and men (P = 0.54), between individuals with and without family history of CRC in first-degree relative (P = 0.64), between tumor anatomical locations (P = 0.45), or between MMR-proficient and MMR-deficient cases (P = 0.54). Conclusion: Cholecystectomy is not a substantial risk factor for CRC, regardless of sex, family history, anatomical location, or tumor MMR status.

Original languageEnglish (US)
Pages (from-to)1451-1457
Number of pages7
JournalInternational Journal of Colorectal Disease
Volume31
Issue number8
DOIs
StatePublished - Aug 1 2016

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Cholecystectomy
Colorectal Neoplasms
DNA Mismatch Repair
Registries
Neoplasms
Gallbladder Diseases
Turcot syndrome
Spouses
Colonic Neoplasms
Population
Canada
Logistic Models
Odds Ratio
Confidence Intervals

Keywords

  • Cholecystectomy
  • Colorectal cancer
  • Gallbladder
  • Mismatch repair

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Shang, J., Reece, J. C., Buchanan, D. D., Giles, G. G., Figueiredo, J. C., Casey, G., ... Win, A. K. (2016). Cholecystectomy and the risk of colorectal cancer by tumor mismatch repair deficiency status. International Journal of Colorectal Disease, 31(8), 1451-1457. https://doi.org/10.1007/s00384-016-2615-5

Cholecystectomy and the risk of colorectal cancer by tumor mismatch repair deficiency status. / Shang, Jie; Reece, Jeanette C.; Buchanan, Daniel D.; Giles, Graham G.; Figueiredo, Jane C.; Casey, Graham; Gallinger, Steven; Thibodeau, Stephen N; Lindor, Noralane Morey; Newcomb, Polly A.; Potter, John D.; Baron, John A.; Hopper, John L.; Jenkins, Mark A.; Win, Aung Ko.

In: International Journal of Colorectal Disease, Vol. 31, No. 8, 01.08.2016, p. 1451-1457.

Research output: Contribution to journalArticle

Shang, J, Reece, JC, Buchanan, DD, Giles, GG, Figueiredo, JC, Casey, G, Gallinger, S, Thibodeau, SN, Lindor, NM, Newcomb, PA, Potter, JD, Baron, JA, Hopper, JL, Jenkins, MA & Win, AK 2016, 'Cholecystectomy and the risk of colorectal cancer by tumor mismatch repair deficiency status', International Journal of Colorectal Disease, vol. 31, no. 8, pp. 1451-1457. https://doi.org/10.1007/s00384-016-2615-5
Shang, Jie ; Reece, Jeanette C. ; Buchanan, Daniel D. ; Giles, Graham G. ; Figueiredo, Jane C. ; Casey, Graham ; Gallinger, Steven ; Thibodeau, Stephen N ; Lindor, Noralane Morey ; Newcomb, Polly A. ; Potter, John D. ; Baron, John A. ; Hopper, John L. ; Jenkins, Mark A. ; Win, Aung Ko. / Cholecystectomy and the risk of colorectal cancer by tumor mismatch repair deficiency status. In: International Journal of Colorectal Disease. 2016 ; Vol. 31, No. 8. pp. 1451-1457.
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abstract = "Purpose: Gallbladder diseases and cholecystectomy may play a role in the development of colorectal cancer (CRC). Our aim was to investigate the association between cholecystectomy and CRC risk overall and by sex, family history, anatomical location, and tumor mismatch repair (MMR) status. Methods: This study comprised 5847 incident CRC cases recruited from population cancer registries in Australia, Canada, and the USA into the Colon Cancer Family Registry between 1997 and 2012 and 4970 controls with no personal history of CRC who were either randomly selected from the general population or were spouses of the cases. The association between cholecystectomy and CRC was estimated using logistic regression, after adjusting for confounding factors. Results: Overall, there was no evidence for an association between cholecystectomy and CRC (odds ratio [OR] = 0.88, 95 {\%} confidence interval 0.73, 1.08). In the stratified analyses, there was no evidence for a difference in the association between women and men (P = 0.54), between individuals with and without family history of CRC in first-degree relative (P = 0.64), between tumor anatomical locations (P = 0.45), or between MMR-proficient and MMR-deficient cases (P = 0.54). Conclusion: Cholecystectomy is not a substantial risk factor for CRC, regardless of sex, family history, anatomical location, or tumor MMR status.",
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AU - Figueiredo, Jane C.

AU - Casey, Graham

AU - Gallinger, Steven

AU - Thibodeau, Stephen N

AU - Lindor, Noralane Morey

AU - Newcomb, Polly A.

AU - Potter, John D.

AU - Baron, John A.

AU - Hopper, John L.

AU - Jenkins, Mark A.

AU - Win, Aung Ko

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N2 - Purpose: Gallbladder diseases and cholecystectomy may play a role in the development of colorectal cancer (CRC). Our aim was to investigate the association between cholecystectomy and CRC risk overall and by sex, family history, anatomical location, and tumor mismatch repair (MMR) status. Methods: This study comprised 5847 incident CRC cases recruited from population cancer registries in Australia, Canada, and the USA into the Colon Cancer Family Registry between 1997 and 2012 and 4970 controls with no personal history of CRC who were either randomly selected from the general population or were spouses of the cases. The association between cholecystectomy and CRC was estimated using logistic regression, after adjusting for confounding factors. Results: Overall, there was no evidence for an association between cholecystectomy and CRC (odds ratio [OR] = 0.88, 95 % confidence interval 0.73, 1.08). In the stratified analyses, there was no evidence for a difference in the association between women and men (P = 0.54), between individuals with and without family history of CRC in first-degree relative (P = 0.64), between tumor anatomical locations (P = 0.45), or between MMR-proficient and MMR-deficient cases (P = 0.54). Conclusion: Cholecystectomy is not a substantial risk factor for CRC, regardless of sex, family history, anatomical location, or tumor MMR status.

AB - Purpose: Gallbladder diseases and cholecystectomy may play a role in the development of colorectal cancer (CRC). Our aim was to investigate the association between cholecystectomy and CRC risk overall and by sex, family history, anatomical location, and tumor mismatch repair (MMR) status. Methods: This study comprised 5847 incident CRC cases recruited from population cancer registries in Australia, Canada, and the USA into the Colon Cancer Family Registry between 1997 and 2012 and 4970 controls with no personal history of CRC who were either randomly selected from the general population or were spouses of the cases. The association between cholecystectomy and CRC was estimated using logistic regression, after adjusting for confounding factors. Results: Overall, there was no evidence for an association between cholecystectomy and CRC (odds ratio [OR] = 0.88, 95 % confidence interval 0.73, 1.08). In the stratified analyses, there was no evidence for a difference in the association between women and men (P = 0.54), between individuals with and without family history of CRC in first-degree relative (P = 0.64), between tumor anatomical locations (P = 0.45), or between MMR-proficient and MMR-deficient cases (P = 0.54). Conclusion: Cholecystectomy is not a substantial risk factor for CRC, regardless of sex, family history, anatomical location, or tumor MMR status.

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