Abstract
Purpose: Gallbladder diseases and cholecystectomy may play a role in the development of colorectal cancer (CRC). Our aim was to investigate the association between cholecystectomy and CRC risk overall and by sex, family history, anatomical location, and tumor mismatch repair (MMR) status. Methods: This study comprised 5847 incident CRC cases recruited from population cancer registries in Australia, Canada, and the USA into the Colon Cancer Family Registry between 1997 and 2012 and 4970 controls with no personal history of CRC who were either randomly selected from the general population or were spouses of the cases. The association between cholecystectomy and CRC was estimated using logistic regression, after adjusting for confounding factors. Results: Overall, there was no evidence for an association between cholecystectomy and CRC (odds ratio [OR] = 0.88, 95 % confidence interval 0.73, 1.08). In the stratified analyses, there was no evidence for a difference in the association between women and men (P = 0.54), between individuals with and without family history of CRC in first-degree relative (P = 0.64), between tumor anatomical locations (P = 0.45), or between MMR-proficient and MMR-deficient cases (P = 0.54). Conclusion: Cholecystectomy is not a substantial risk factor for CRC, regardless of sex, family history, anatomical location, or tumor MMR status.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1451-1457 |
| Number of pages | 7 |
| Journal | International Journal of Colorectal Disease |
| Volume | 31 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 1 2016 |
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Keywords
- Cholecystectomy
- Colorectal cancer
- Gallbladder
- Mismatch repair
ASJC Scopus subject areas
- Gastroenterology
Cite this
Cholecystectomy and the risk of colorectal cancer by tumor mismatch repair deficiency status. / Shang, Jie; Reece, Jeanette C.; Buchanan, Daniel D.; Giles, Graham G.; Figueiredo, Jane C.; Casey, Graham; Gallinger, Steven; Thibodeau, Stephen N; Lindor, Noralane Morey; Newcomb, Polly A.; Potter, John D.; Baron, John A.; Hopper, John L.; Jenkins, Mark A.; Win, Aung Ko.
In: International Journal of Colorectal Disease, Vol. 31, No. 8, 01.08.2016, p. 1451-1457.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cholecystectomy and the risk of colorectal cancer by tumor mismatch repair deficiency status
AU - Shang, Jie
AU - Reece, Jeanette C.
AU - Buchanan, Daniel D.
AU - Giles, Graham G.
AU - Figueiredo, Jane C.
AU - Casey, Graham
AU - Gallinger, Steven
AU - Thibodeau, Stephen N
AU - Lindor, Noralane Morey
AU - Newcomb, Polly A.
AU - Potter, John D.
AU - Baron, John A.
AU - Hopper, John L.
AU - Jenkins, Mark A.
AU - Win, Aung Ko
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Purpose: Gallbladder diseases and cholecystectomy may play a role in the development of colorectal cancer (CRC). Our aim was to investigate the association between cholecystectomy and CRC risk overall and by sex, family history, anatomical location, and tumor mismatch repair (MMR) status. Methods: This study comprised 5847 incident CRC cases recruited from population cancer registries in Australia, Canada, and the USA into the Colon Cancer Family Registry between 1997 and 2012 and 4970 controls with no personal history of CRC who were either randomly selected from the general population or were spouses of the cases. The association between cholecystectomy and CRC was estimated using logistic regression, after adjusting for confounding factors. Results: Overall, there was no evidence for an association between cholecystectomy and CRC (odds ratio [OR] = 0.88, 95 % confidence interval 0.73, 1.08). In the stratified analyses, there was no evidence for a difference in the association between women and men (P = 0.54), between individuals with and without family history of CRC in first-degree relative (P = 0.64), between tumor anatomical locations (P = 0.45), or between MMR-proficient and MMR-deficient cases (P = 0.54). Conclusion: Cholecystectomy is not a substantial risk factor for CRC, regardless of sex, family history, anatomical location, or tumor MMR status.
AB - Purpose: Gallbladder diseases and cholecystectomy may play a role in the development of colorectal cancer (CRC). Our aim was to investigate the association between cholecystectomy and CRC risk overall and by sex, family history, anatomical location, and tumor mismatch repair (MMR) status. Methods: This study comprised 5847 incident CRC cases recruited from population cancer registries in Australia, Canada, and the USA into the Colon Cancer Family Registry between 1997 and 2012 and 4970 controls with no personal history of CRC who were either randomly selected from the general population or were spouses of the cases. The association between cholecystectomy and CRC was estimated using logistic regression, after adjusting for confounding factors. Results: Overall, there was no evidence for an association between cholecystectomy and CRC (odds ratio [OR] = 0.88, 95 % confidence interval 0.73, 1.08). In the stratified analyses, there was no evidence for a difference in the association between women and men (P = 0.54), between individuals with and without family history of CRC in first-degree relative (P = 0.64), between tumor anatomical locations (P = 0.45), or between MMR-proficient and MMR-deficient cases (P = 0.54). Conclusion: Cholecystectomy is not a substantial risk factor for CRC, regardless of sex, family history, anatomical location, or tumor MMR status.
KW - Cholecystectomy
KW - Colorectal cancer
KW - Gallbladder
KW - Mismatch repair
UR - http://www.scopus.com/inward/record.url?scp=84973663767&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84973663767&partnerID=8YFLogxK
U2 - 10.1007/s00384-016-2615-5
DO - 10.1007/s00384-016-2615-5
M3 - Article
C2 - 27286977
AN - SCOPUS:84973663767
VL - 31
SP - 1451
EP - 1457
JO - International Journal of Colorectal Disease
JF - International Journal of Colorectal Disease
SN - 0179-1958
IS - 8
ER -