Cholangiocyte pathobiology

Jesus M. Banales, Robert C Huebert, Tom Karlsen, Mario Strazzabosco, Nicholas F La Russo, Gregory James Gores

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Cholangiocytes, the epithelial cells lining the intrahepatic and extrahepatic bile ducts, are highly specialized cells residing in a complex anatomic niche where they participate in bile production and homeostasis. Cholangiocytes are damaged in a variety of human diseases termed cholangiopathies, often causing advanced liver failure. The regulation of cholangiocyte transport properties is increasingly understood, as is their anatomical and functional heterogeneity along the biliary tract. Furthermore, cholangiocytes are pivotal in liver regeneration, especially when hepatocyte regeneration is compromised. The role of cholangiocytes in innate and adaptive immune responses, a critical subject relevant to immune-mediated cholangiopathies, is also emerging. Finally, reactive ductular cells are present in many cholestatic and other liver diseases. In chronic disease states, this repair response contributes to liver inflammation, fibrosis and carcinogenesis and is a subject of intense investigation. This Review highlights advances in cholangiocyte research, especially their role in development and liver regeneration, their functional and biochemical heterogeneity, their activation and involvement in inflammation and fibrosis and their engagement with the immune system. We aim to focus further attention on cholangiocyte pathobiology and the search for new disease-modifying therapies targeting the cholangiopathies.

Original languageEnglish (US)
JournalNature Reviews Gastroenterology and Hepatology
DOIs
StatePublished - Jan 1 2019

Fingerprint

Liver Regeneration
Inflammation
Intrahepatic Bile Ducts
Extrahepatic Bile Ducts
Liver Failure
Biliary Tract
Adaptive Immunity
Innate Immunity
Bile
Liver Cirrhosis
Liver Diseases
Regeneration
Hepatocytes
Immune System
Carcinogenesis
Homeostasis
Fibrosis
Chronic Disease
Epithelial Cells
Research

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Cholangiocyte pathobiology. / Banales, Jesus M.; Huebert, Robert C; Karlsen, Tom; Strazzabosco, Mario; La Russo, Nicholas F; Gores, Gregory James.

In: Nature Reviews Gastroenterology and Hepatology, 01.01.2019.

Research output: Contribution to journalReview article

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