Cholangiocyte biology

Pamela Tietz, Nicholas F. LaRusso

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Cholangiocytes are of considerable intrinsic biologic interest, particularly with regard to their roles in the transport of water, ions, and solutes, and to their heterogeneity and proliferative capacity. Cholangiocytes represent an important target of study in the cholangiopathies, a group of genetic developmental and acquired diseases of the liver. New biologic concepts continue to evolve through the use of experimental models (eg. knockout mice and selective gene silencing) and enhanced approaches to three-dimensional modeling and microscopy. The role of the cholangiocyte cytoskeleton in transport and intracellular trafficking has been recently recognized. These paradigms provide a framework for further understanding the mechanisms modulating normal cholangiocyte growth, transport, and signaling, and the abnormalities that result in disease.

Original languageEnglish (US)
Pages (from-to)264-269
Number of pages6
JournalCurrent Opinion in Gastroenterology
Volume19
Issue number3
DOIs
StatePublished - May 1 2003

ASJC Scopus subject areas

  • Gastroenterology

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