Cholangiocarcinoma: Emerging approaches to a challenging cancer

Tushar Patel, Pankaj Singh

Research output: Contribution to journalReview articlepeer-review

57 Scopus citations

Abstract

PURPOSE OF REVIEW: Cholangiocarcinomas are malignancies arising from biliary tract epithelia that are associated with a poor prognosis. The diagnosis, evaluation and management of these tumors continue to be clinically challenging. In this review, we will discuss recent information that may influence the approach to the diagnosis and management of this devastating tumor. RECENT FINDINGS: Epidemiological studies are defining patient groups at increased risk of cancer in regions of low prevalence. Emerging approaches that may improve evaluation and management include the potential use of genomic and proteomic markers, cytogenetic and digital image analysis, endoscopic ultrasound with fine needle aspiration, and cholangioscopy. Adoption of aggressive surgical approaches along with the use of preoperative portal vein embolization, hepatic and caudate lobe resection and preoperative laparoscopy may improve survival. SUMMARY: Recent conceptual and technical advances will impact the clinical approach to cholangiocarcinoma and offer the promise of improving outcomes from this difficult tumor.

Original languageEnglish (US)
Pages (from-to)317-323
Number of pages7
JournalCurrent Opinion in Gastroenterology
Volume23
Issue number3
DOIs
StatePublished - May 2007

Keywords

  • Biliary tract malignancy
  • Diagnosis
  • Epidemiology
  • Management
  • Therapy

ASJC Scopus subject areas

  • Gastroenterology

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