Chloroquine-induced cardiomyopathy-echocardiographic features

Tasneem Zehra Naqvi, Daniel Luthringer, Alberto Marchevsky, Rola Saouf, Khawar Gul, Neil A. Buchbinder

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

A 61-year-old woman with a 30-year history of systemic lupus erythematosus treated with chloroquine sulfate presented with complete heart block, congestive heart failure, and findings of restrictive cardiomyopathy on echocardiogram. Thickening of mitral, aortic, and tricuspid valves along with mild to moderate valve regurgitation was also present. Magnetic resonance imaging showed increased gadolinium uptake in the interventricular septum and the left ventricular lateral wall. Endomyocardial biopsy specimen showed marked myocardial cytoplasmic vacuolation and extensive myelin figures. Seven months after discontinuation of chloroquine, she showed significant clinical improvement and reversal of cardiomyopathy on echocardiography. This is the first case report describing a cardiomyopathy with prolonged use of chloroquine involving the conduction system, cardiac valves, and the myocardium with reversal on discontinuation of the drug.

Original languageEnglish (US)
Pages (from-to)383-387
Number of pages5
JournalJournal of the American Society of Echocardiography
Volume18
Issue number4
DOIs
StatePublished - Apr 2005
Externally publishedYes

Fingerprint

Chloroquine
Cardiomyopathies
Restrictive Cardiomyopathy
Ventricular Septum
Heart Block
Tricuspid Valve
Heart Valves
Gadolinium
Myelin Sheath
Aortic Valve
Mitral Valve
Systemic Lupus Erythematosus
Echocardiography
Myocardium
Heart Failure
Magnetic Resonance Imaging
Biopsy
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Chloroquine-induced cardiomyopathy-echocardiographic features. / Naqvi, Tasneem Zehra; Luthringer, Daniel; Marchevsky, Alberto; Saouf, Rola; Gul, Khawar; Buchbinder, Neil A.

In: Journal of the American Society of Echocardiography, Vol. 18, No. 4, 04.2005, p. 383-387.

Research output: Contribution to journalArticle

Naqvi, Tasneem Zehra ; Luthringer, Daniel ; Marchevsky, Alberto ; Saouf, Rola ; Gul, Khawar ; Buchbinder, Neil A. / Chloroquine-induced cardiomyopathy-echocardiographic features. In: Journal of the American Society of Echocardiography. 2005 ; Vol. 18, No. 4. pp. 383-387.
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