Chimerism in children with juvenile dermatomyositis

Ann M. Reed, Aaron Harwood, Yoana J. Picornell, Deborah W. Kredich

Research output: Contribution to journalArticlepeer-review

146 Scopus citations

Abstract

Juvenile dermatomyositis is a disease with similarities to chronic graft-versus-host disease. To identify whether chimerism is present in juvenile dermatomyositis, we investigated the families of 15 children with the disorder. Chimerism was identified by PCR in 13 of the 15 affected children, compared with five of 35 siblings (p<0.0001). Maternal cells among peripheral-blood mononuclear cells were detected in 11 of the 15 boys, compared with five of 17 unaffected controls (p=0.02), and in muscle tissue of 12 of 15 compared with two of ten unaffected siblings (p=0.005). These results suggest that chimerism may be involved in juvenile dermatomyositis.

Original languageEnglish (US)
Pages (from-to)2156-2157
Number of pages2
JournalLancet
Volume356
Issue number9248
DOIs
StatePublished - Dec 23 2000

ASJC Scopus subject areas

  • Medicine(all)

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