Childhood-onset porphyria cutanea tarda: Successful therapy with low- dose hydroxychloroquine (Plaquenil)

A. J. Bruce, I. Ahmed

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

We describe a 4-year-old girl with a spontaneous blistering disorder that was consistent with porphyria cutanea tarda (PCT). There was no familial history of the disease or any obvious causative factors present. Oral hydroxychloroquine (3 mg/kg) was given twice weekly along with vitamin E (200 U/d) as an antioxidant. Within 6 weeks, marked decreased blistering occurred and by 12 weeks no blistering was evident. Despite clinical improvement and tolerance of hydroxychloroquine, urinary uroporphyrin, asparate amino- transferase, and ferritin levels continued to rise reaching peak levels at 16 weeks of therapy. Near total biochemical remission was observed at 40 weeks and all therapy was discontinued at 60 weeks.

Original languageEnglish (US)
Pages (from-to)810-814
Number of pages5
JournalJournal of the American Academy of Dermatology
Volume38
Issue number5 II
DOIs
StatePublished - Jan 1 1998

ASJC Scopus subject areas

  • Dermatology

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