Child Development and Structural Variation in the Human Genome

Ying Zhang; Rajini Haraksingh; Fabian Grubert; Alexej Abyzov; Mark Gerstein; Sherman Weissman; Alexander E. Urban

doi:10.1111/cdev.12051

Child Development and Structural Variation in the Human Genome

Ying Zhang, Rajini Haraksingh, Fabian Grubert, Alexej Abyzov, Mark Gerstein, Sherman Weissman, Alexander E. Urban

Quantitative Health Sciences

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Structural variation of the human genome sequence is the insertion, deletion, or rearrangement of stretches of DNA sequence sized from around 1,000 to millions of base pairs. Over the past few years, structural variation has been shown to be far more common in human genomes than previously thought. Very little is currently known about the effects of structural variation on normal child development, but such effects could be of considerable significance. This review provides an overview of the phenomenon of structural variation in the human genome sequence, describing the novel genomics technologies that are revolutionizing the way structural variation is studied and giving examples of genomic structural variations that affect child development.

Original language	English (US)
Pages (from-to)	34-48
Number of pages	15
Journal	Child Development
Volume	84
Issue number	1
DOIs	https://doi.org/10.1111/cdev.12051
State	Published - Jan 2013

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Education
Developmental and Educational Psychology

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AU - Weissman, Sherman

AU - Urban, Alexander E.

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Child Development and Structural Variation in the Human Genome

Abstract

ASJC Scopus subject areas

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