Chest pain after nontransmural infarction: The absence of remediable coronary vasospasm

Paul R. Eisenberg, Robert G. Lee, Daniel R. Biello, Edward M. Geltman, Allan S Jaffe

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

To assess the contribution of coronary vasospasm to chest pain in patients with nontransmural myocardial infarction, we performed a controlled trial of prophylactic antivasospastic therapy. Fifty patients with nontransmural infarction received either nifedipine or placebo in a double-blind randomized trial. Chest pain occurred in 52% of treated patients (38 episodes on 35 days) compared to 48% of control patients (42 episodes on 33 days). Concurrent therapy was comparable in the two groups. Recurrent infarction occurred in 12% and was comparable between groups. Ejection fraction was similar and was unchanged throughout the study in both groups. Logistic regression failed to identify predictors for recurrent chest discomfort. These data indicate that potent antivasospastic therapy does not reduce the incidence of recurrent chest pain or infarction. Thus, remediable coronary vasospasm is not likely to be a major cause of post infarction ischemia in patients with nontransmural infarction.

Original languageEnglish (US)
Pages (from-to)515-521
Number of pages7
JournalAmerican Heart Journal
Volume110
Issue number3
DOIs
StatePublished - 1985
Externally publishedYes

Fingerprint

Coronary Vasospasm
Chest Pain
Infarction
Nifedipine
Thorax
Therapeutics
Ischemia
Logistic Models
Myocardial Infarction
Placebos
Incidence

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Chest pain after nontransmural infarction : The absence of remediable coronary vasospasm. / Eisenberg, Paul R.; Lee, Robert G.; Biello, Daniel R.; Geltman, Edward M.; Jaffe, Allan S.

In: American Heart Journal, Vol. 110, No. 3, 1985, p. 515-521.

Research output: Contribution to journalArticle

Eisenberg, Paul R. ; Lee, Robert G. ; Biello, Daniel R. ; Geltman, Edward M. ; Jaffe, Allan S. / Chest pain after nontransmural infarction : The absence of remediable coronary vasospasm. In: American Heart Journal. 1985 ; Vol. 110, No. 3. pp. 515-521.
@article{13ab60fa36124379ab9928439429ef9b,
title = "Chest pain after nontransmural infarction: The absence of remediable coronary vasospasm",
abstract = "To assess the contribution of coronary vasospasm to chest pain in patients with nontransmural myocardial infarction, we performed a controlled trial of prophylactic antivasospastic therapy. Fifty patients with nontransmural infarction received either nifedipine or placebo in a double-blind randomized trial. Chest pain occurred in 52{\%} of treated patients (38 episodes on 35 days) compared to 48{\%} of control patients (42 episodes on 33 days). Concurrent therapy was comparable in the two groups. Recurrent infarction occurred in 12{\%} and was comparable between groups. Ejection fraction was similar and was unchanged throughout the study in both groups. Logistic regression failed to identify predictors for recurrent chest discomfort. These data indicate that potent antivasospastic therapy does not reduce the incidence of recurrent chest pain or infarction. Thus, remediable coronary vasospasm is not likely to be a major cause of post infarction ischemia in patients with nontransmural infarction.",
author = "Eisenberg, {Paul R.} and Lee, {Robert G.} and Biello, {Daniel R.} and Geltman, {Edward M.} and Jaffe, {Allan S}",
year = "1985",
doi = "10.1016/0002-8703(85)90068-7",
language = "English (US)",
volume = "110",
pages = "515--521",
journal = "American Heart Journal",
issn = "0002-8703",
publisher = "Mosby Inc.",
number = "3",

}

TY - JOUR

T1 - Chest pain after nontransmural infarction

T2 - The absence of remediable coronary vasospasm

AU - Eisenberg, Paul R.

AU - Lee, Robert G.

AU - Biello, Daniel R.

AU - Geltman, Edward M.

AU - Jaffe, Allan S

PY - 1985

Y1 - 1985

N2 - To assess the contribution of coronary vasospasm to chest pain in patients with nontransmural myocardial infarction, we performed a controlled trial of prophylactic antivasospastic therapy. Fifty patients with nontransmural infarction received either nifedipine or placebo in a double-blind randomized trial. Chest pain occurred in 52% of treated patients (38 episodes on 35 days) compared to 48% of control patients (42 episodes on 33 days). Concurrent therapy was comparable in the two groups. Recurrent infarction occurred in 12% and was comparable between groups. Ejection fraction was similar and was unchanged throughout the study in both groups. Logistic regression failed to identify predictors for recurrent chest discomfort. These data indicate that potent antivasospastic therapy does not reduce the incidence of recurrent chest pain or infarction. Thus, remediable coronary vasospasm is not likely to be a major cause of post infarction ischemia in patients with nontransmural infarction.

AB - To assess the contribution of coronary vasospasm to chest pain in patients with nontransmural myocardial infarction, we performed a controlled trial of prophylactic antivasospastic therapy. Fifty patients with nontransmural infarction received either nifedipine or placebo in a double-blind randomized trial. Chest pain occurred in 52% of treated patients (38 episodes on 35 days) compared to 48% of control patients (42 episodes on 33 days). Concurrent therapy was comparable in the two groups. Recurrent infarction occurred in 12% and was comparable between groups. Ejection fraction was similar and was unchanged throughout the study in both groups. Logistic regression failed to identify predictors for recurrent chest discomfort. These data indicate that potent antivasospastic therapy does not reduce the incidence of recurrent chest pain or infarction. Thus, remediable coronary vasospasm is not likely to be a major cause of post infarction ischemia in patients with nontransmural infarction.

UR - http://www.scopus.com/inward/record.url?scp=0022189544&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022189544&partnerID=8YFLogxK

U2 - 10.1016/0002-8703(85)90068-7

DO - 10.1016/0002-8703(85)90068-7

M3 - Article

C2 - 3898794

AN - SCOPUS:0022189544

VL - 110

SP - 515

EP - 521

JO - American Heart Journal

JF - American Heart Journal

SN - 0002-8703

IS - 3

ER -