Chemotherapy-induced peripheral neurotoxicity: A multifaceted, still unsolved issue

on behalf of the Toxic Neuropathy Consortium of the Peripheral Nerve Society

Research output: Contribution to journalReview article

Abstract

Chemotherapy-induced peripheral neurotoxicity (CIPN) is a potentially dose-limiting side effect of several commonly used cytotoxic chemotherapy agents. The main pharmacological classes that may cause CIPN include classical anticancer drugs, as well as the recently introduced immune checkpoint inhibitors and antibody drug conjugates. The absence of a complete knowledge of CIPN pathophysiology is only one of the several unsolved issues related to CIPN. Among some of the most relevant aspects of CIPN deserving further attention include the real number of patients exposed to the risk of CIPN, the long-term impact on cancer survivors' quality of life due to incomplete recovery from CIPN, the economic burden related to acute and chronic CIPN, and the different perspective and education of the healthcare specialists in charge of managing patients with CIPN. Overall, CIPN remains a very challenging area of research as there are still several unresolved issues to be addressed in the future. In this special issue, the multifaceted profile of CIPN will be presented, with particular emphasis on bolstering the need to develop more optimized outcome measures than the existing ones to accurately evaluate the extent of CIPN, but also to ascertain the differences in the incidence, risk factors, clinical phenotype, and management of CIPN, according to the most commonly used neurotoxic chemotherapy classes. Perspectives for future research to pursue in order to cover the gaps in knowledge in the CIPN field will also be discussed.

Original languageEnglish (US)
Pages (from-to)S6-S12
JournalJournal of the Peripheral Nervous System
Volume24
Issue numberS2
DOIs
StatePublished - Oct 1 2019

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Drug Therapy
Cytotoxins
Pharmaceutical Preparations
Survivors
Economics
Quality of Life
Outcome Assessment (Health Care)
Pharmacology
Delivery of Health Care
Phenotype
Education
Antibodies
Incidence

Keywords

  • adult
  • chemotherapy
  • children
  • economic costs
  • neurotoxicity

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

on behalf of the Toxic Neuropathy Consortium of the Peripheral Nerve Society (2019). Chemotherapy-induced peripheral neurotoxicity: A multifaceted, still unsolved issue. Journal of the Peripheral Nervous System, 24(S2), S6-S12. https://doi.org/10.1111/jns.12337

Chemotherapy-induced peripheral neurotoxicity : A multifaceted, still unsolved issue. / on behalf of the Toxic Neuropathy Consortium of the Peripheral Nerve Society.

In: Journal of the Peripheral Nervous System, Vol. 24, No. S2, 01.10.2019, p. S6-S12.

Research output: Contribution to journalReview article

on behalf of the Toxic Neuropathy Consortium of the Peripheral Nerve Society 2019, 'Chemotherapy-induced peripheral neurotoxicity: A multifaceted, still unsolved issue', Journal of the Peripheral Nervous System, vol. 24, no. S2, pp. S6-S12. https://doi.org/10.1111/jns.12337
on behalf of the Toxic Neuropathy Consortium of the Peripheral Nerve Society. Chemotherapy-induced peripheral neurotoxicity: A multifaceted, still unsolved issue. Journal of the Peripheral Nervous System. 2019 Oct 1;24(S2):S6-S12. https://doi.org/10.1111/jns.12337
on behalf of the Toxic Neuropathy Consortium of the Peripheral Nerve Society. / Chemotherapy-induced peripheral neurotoxicity : A multifaceted, still unsolved issue. In: Journal of the Peripheral Nervous System. 2019 ; Vol. 24, No. S2. pp. S6-S12.
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