Chemoprevention of intestinal tumorigenesis by nabumetone: Induction of apoptosis and Bcl-2 downregulation

H. K. Roy, W. J. Karoski, A. Ratashak, T. C. Smyrk

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Treatment of MIN mice with the nonsteroidal anti-inflammatory drug, nabumetone, resulted in a dose-dependent suppression of intestinal tumorigenesis. In both the uninvolved MIN mouse colonic epithelium and HT-29 colon cancer cells, nabumetone downregulated the anti-apoptotic protein, Bcl-2, with concomitant induction of apoptosis, suggesting a potential mechanism for colon cancer chemoprevention.

Original languageEnglish (US)
Pages (from-to)1412-1416
Number of pages5
JournalBritish journal of cancer
Volume84
Issue number10
DOIs
StatePublished - May 18 2001

Keywords

  • Apoptosis
  • Colon cancer
  • Nonsteroidal anti-inflammatory drugs

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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