Chemoprevention of intestinal tumorigenesis by nabumetone: Induction of apoptosis and Bcl-2 downregulation

H. K. Roy, W. J. Karoski, A. Ratashak, Thomas Christopher Smyrk

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Treatment of MIN mice with the nonsteroidal anti-inflammatory drug, nabumetone, resulted in a dose-dependent suppression of intestinal tumorigenesis. In both the uninvolved MIN mouse colonic epithelium and HT-29 colon cancer cells, nabumetone downregulated the anti-apoptotic protein, Bcl-2, with concomitant induction of apoptosis, suggesting a potential mechanism for colon cancer chemoprevention.

Original languageEnglish (US)
Pages (from-to)1412-1416
Number of pages5
JournalBritish Journal of Cancer
Volume84
Issue number10
DOIs
StatePublished - May 18 2001

Fingerprint

nabumetone
Chemoprevention
Colonic Neoplasms
Carcinogenesis
Down-Regulation
Apoptosis
Apoptosis Regulatory Proteins
Anti-Inflammatory Agents
Epithelium
Pharmaceutical Preparations
Therapeutics

Keywords

  • Apoptosis
  • Colon cancer
  • Nonsteroidal anti-inflammatory drugs

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Chemoprevention of intestinal tumorigenesis by nabumetone : Induction of apoptosis and Bcl-2 downregulation. / Roy, H. K.; Karoski, W. J.; Ratashak, A.; Smyrk, Thomas Christopher.

In: British Journal of Cancer, Vol. 84, No. 10, 18.05.2001, p. 1412-1416.

Research output: Contribution to journalArticle

Roy, H. K. ; Karoski, W. J. ; Ratashak, A. ; Smyrk, Thomas Christopher. / Chemoprevention of intestinal tumorigenesis by nabumetone : Induction of apoptosis and Bcl-2 downregulation. In: British Journal of Cancer. 2001 ; Vol. 84, No. 10. pp. 1412-1416.
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