Chemoprevention in Barrett's oesophagus

Anushka Baruah, Navtej S. Buttar

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Increasing incidence of oesophageal adenocarcinoma along with poor survival entails novel preventive strategies. Agents that target pro-oncogenic pathways in Barrett's mucosa could halt this neoplastic transformation. In this review, we will use epidemiological associations and molecular mechanisms to identify novel chemoprevention targets in Barrett's oesophagus. We will also discuss recent chemoprevention trials.

Original languageEnglish (US)
Pages (from-to)151-165
Number of pages15
JournalBest Practice and Research: Clinical Gastroenterology
Volume29
Issue number1
DOIs
StatePublished - Feb 1 2015

Keywords

  • Barrett's oesophagus(BO)
  • Chemo-preventive agents
  • Oesophageal adenocarcinoma(OAC)
  • Surrogate endpoint markers(SEBs)

ASJC Scopus subject areas

  • Gastroenterology

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