Chemoprevention for prostatic carcinoma: The role of flutamide in patients with prostatic intraepithelial neoplasia

Steven R. Alberts, Michael L. Blute

Research output: Contribution to journalArticle

17 Scopus citations


High-grade prostatic intraepithelial neoplasia (HGPIN) is believed to be a precursor for prostatic adenocarcinoma. The prevalence of prostatic intraepithelial neoplasia (PIN) increases with advancing age. Autopsy studies suggest that PIN may precede the development of prostatic adenocarcinoma by up to 10 years. As such, HGPIN is believed to be a marker of increased risk. This provides a potential opportunity for chemoprevention. Flutamide is 1 agent with potential activity and limited side effects that may act to prevent or delay the onset of prostatic adenocarcinoma in men with HGPIN. A clinical trial is currently underway to assess the efficacy of flutamide.

Original languageEnglish (US)
Pages (from-to)188-190
Number of pages3
Issue number4 SUPPL. 1
StatePublished - Dec 1 2001


ASJC Scopus subject areas

  • Urology

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