Chemokines in cardiovascular diseases: From atherosclerosis and heart failure to allograft arteriopathy

Mohamad H. Yamani, James B. Young

Research output: Contribution to journalReview article

Abstract

Chemokines are a superfamily of structurally related cytokines that mediate leukocyte attraction and migration during inflammatory and immune responses. They are divided into 4 groups (CXC, CX3C, CC, and C), on the basis of their amino acid sequence in relation to their cysteine moieties. Chemokines have been shown to play a pathogenic role in several inflammatory disorders and have been implicated in the pathogenesis of several cardiovascular diseases such as congestive heart failure, atherosclerosis, myocarditis, and ischemia-reperfusion injury. Recently, an important role for chemokines has also been demonstrated in the pathogenesis of acute rejection and allograft vasculopathy following cardiac transplantation. Chemokine antagonism may represent a potential novel therapeutic strategy to attenuate the inflammatory response of several disease processes.

Original languageEnglish (US)
Pages (from-to)205-211
Number of pages7
JournalGraft
Volume5
Issue number4
DOIs
StatePublished - 2002
Externally publishedYes

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Chemokines
Allografts
Atherosclerosis
Cardiovascular Diseases
Heart Failure
Myocarditis
Heart Transplantation
Reperfusion Injury
Cysteine
Amino Acid Sequence
Leukocytes
Cytokines
Therapeutics

ASJC Scopus subject areas

  • Transplantation

Cite this

Chemokines in cardiovascular diseases : From atherosclerosis and heart failure to allograft arteriopathy. / Yamani, Mohamad H.; Young, James B.

In: Graft, Vol. 5, No. 4, 2002, p. 205-211.

Research output: Contribution to journalReview article

Yamani, Mohamad H. ; Young, James B. / Chemokines in cardiovascular diseases : From atherosclerosis and heart failure to allograft arteriopathy. In: Graft. 2002 ; Vol. 5, No. 4. pp. 205-211.
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