TY - JOUR
T1 - Chemokines in cardiovascular diseases
T2 - From atherosclerosis and heart failure to allograft arteriopathy
AU - Yamani, Mohamad H.
AU - Young, James B.
PY - 2002/1/1
Y1 - 2002/1/1
N2 - Chemokines are a superfamily of structurally related cytokines that mediate leukocyte attraction and migration during inflammatory and immune responses. They are divided into 4 groups (CXC, CX3C, CC, and C), on the basis of their amino acid sequence in relation to their cysteine moieties. Chemokines have been shown to play a pathogenic role in several inflammatory disorders and have been implicated in the pathogenesis of several cardiovascular diseases such as congestive heart failure, atherosclerosis, myocarditis, and ischemia-reperfusion injury. Recently, an important role for chemokines has also been demonstrated in the pathogenesis of acute rejection and allograft vasculopathy following cardiac transplantation. Chemokine antagonism may represent a potential novel therapeutic strategy to attenuate the inflammatory response of several disease processes.
AB - Chemokines are a superfamily of structurally related cytokines that mediate leukocyte attraction and migration during inflammatory and immune responses. They are divided into 4 groups (CXC, CX3C, CC, and C), on the basis of their amino acid sequence in relation to their cysteine moieties. Chemokines have been shown to play a pathogenic role in several inflammatory disorders and have been implicated in the pathogenesis of several cardiovascular diseases such as congestive heart failure, atherosclerosis, myocarditis, and ischemia-reperfusion injury. Recently, an important role for chemokines has also been demonstrated in the pathogenesis of acute rejection and allograft vasculopathy following cardiac transplantation. Chemokine antagonism may represent a potential novel therapeutic strategy to attenuate the inflammatory response of several disease processes.
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U2 - 10.1177/152216280200500403
DO - 10.1177/152216280200500403
M3 - Review article
AN - SCOPUS:0036301086
SN - 1522-1628
VL - 5
SP - 205
EP - 211
JO - Graft
JF - Graft
IS - 4
ER -