Chemokines in cardiovascular diseases: From atherosclerosis and heart failure to allograft arteriopathy

Mohamad H. Yamani, James B. Young

Research output: Contribution to journalReview article

Abstract

Chemokines are a superfamily of structurally related cytokines that mediate leukocyte attraction and migration during inflammatory and immune responses. They are divided into 4 groups (CXC, CX3C, CC, and C), on the basis of their amino acid sequence in relation to their cysteine moieties. Chemokines have been shown to play a pathogenic role in several inflammatory disorders and have been implicated in the pathogenesis of several cardiovascular diseases such as congestive heart failure, atherosclerosis, myocarditis, and ischemia-reperfusion injury. Recently, an important role for chemokines has also been demonstrated in the pathogenesis of acute rejection and allograft vasculopathy following cardiac transplantation. Chemokine antagonism may represent a potential novel therapeutic strategy to attenuate the inflammatory response of several disease processes.

Original languageEnglish (US)
Pages (from-to)205-211
Number of pages7
JournalGraft
Volume5
Issue number4
DOIs
StatePublished - Jan 1 2002

ASJC Scopus subject areas

  • Transplantation

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