TY - JOUR
T1 - Chemokine-Mediated Choreography of Thymocyte Development and Selection
AU - Lancaster, Jessica N.
AU - Li, Yu
AU - Ehrlich, Lauren I.R.
N1 - Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2018/2
Y1 - 2018/2
N2 - As they differentiate, thymocytes encounter spatially restricted cues critical for differentiation and selection of a functional, self-tolerant T cell repertoire. Sequential migration of developing T cells through distinct thymic microenvironments is enforced by the ordered expression of chemokine receptors. Herein, we provide an updated perspective on T cell differentiation through the lens of recent advances that illuminate the dynamics of chemokine-driven thymocyte migration, localization, and interactions with stromal cells. We consider these findings in the context of earlier groundwork exploring the contribution of chemokines to T cell development, recent advances regarding the specificity of chemokine signaling, and novel techniques for evaluating the T cell repertoire. We suggest future research should amalgamate visualization of localized cellular interactions with downstream molecular signals.
AB - As they differentiate, thymocytes encounter spatially restricted cues critical for differentiation and selection of a functional, self-tolerant T cell repertoire. Sequential migration of developing T cells through distinct thymic microenvironments is enforced by the ordered expression of chemokine receptors. Herein, we provide an updated perspective on T cell differentiation through the lens of recent advances that illuminate the dynamics of chemokine-driven thymocyte migration, localization, and interactions with stromal cells. We consider these findings in the context of earlier groundwork exploring the contribution of chemokines to T cell development, recent advances regarding the specificity of chemokine signaling, and novel techniques for evaluating the T cell repertoire. We suggest future research should amalgamate visualization of localized cellular interactions with downstream molecular signals.
UR - http://www.scopus.com/inward/record.url?scp=85034852054&partnerID=8YFLogxK
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U2 - 10.1016/j.it.2017.10.007
DO - 10.1016/j.it.2017.10.007
M3 - Review article
C2 - 29162323
AN - SCOPUS:85034852054
SN - 1471-4906
VL - 39
SP - 86
EP - 98
JO - Trends in Immunology
JF - Trends in Immunology
IS - 2
ER -