Chemokine-Mediated Choreography of Thymocyte Development and Selection

Jessica N. Lancaster, Yu Li, Lauren I.R. Ehrlich

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

As they differentiate, thymocytes encounter spatially restricted cues critical for differentiation and selection of a functional, self-tolerant T cell repertoire. Sequential migration of developing T cells through distinct thymic microenvironments is enforced by the ordered expression of chemokine receptors. Herein, we provide an updated perspective on T cell differentiation through the lens of recent advances that illuminate the dynamics of chemokine-driven thymocyte migration, localization, and interactions with stromal cells. We consider these findings in the context of earlier groundwork exploring the contribution of chemokines to T cell development, recent advances regarding the specificity of chemokine signaling, and novel techniques for evaluating the T cell repertoire. We suggest future research should amalgamate visualization of localized cellular interactions with downstream molecular signals.

Original languageEnglish (US)
Pages (from-to)86-98
Number of pages13
JournalTrends in Immunology
Volume39
Issue number2
DOIs
StatePublished - Feb 2018

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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