Chemokine expression in the central nervous system of mice with a viral disease resembling multiple sclerosis: Roles of CD4+ and CD8+ T cells and viral persistence

R. M. Ransohoff, T. Wei, K. D. Pavelko, J. C. Lee, P. D. Murray, M. Rodriguez

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

During the first 45 days after intracerebral infection with Theiler's murine encephalomyelitis virus (TMEV), the levels of mRNAs encoding chemokines MCP-1/CCL2, RANTES/CCL5, and IP-10/CXCL10 in the central nervous system (CNS) are closely related to the sites of virus gene expression and tissue inflammation. In the present study, these chemokines were monitored during the latter 135 days of a 6-month course of TMEVinduced disease in susceptible (PLJ) or resistant (C57BL/6) mice that possessed or lacked either CD4+ or CD8+ T cells. These data were additionally correlated to mouse genotype, virus persistence in the CNS, antiviral antibody titers, mortality, and the severity of neurological disease. Surprisingly, the major determinant of chemokine expression was virus persistence: the factors of susceptible or resistant genotype, severity of neuropathology, and presence or absence of regulatory T cells exerted minimal effects. Our observations indicated that chemokine expression in the CNS in this chronic viral disorder was intrinsic to the CNS innate immune response to infection and was not governed by elements of the adaptive immune system.

Original languageEnglish (US)
Pages (from-to)2217-2224
Number of pages8
JournalJournal of virology
Volume76
Issue number5
DOIs
StatePublished - 2002

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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