Chemo-enzymatic synthesis of polydimethylsiloxane curcumin copolymer for detection of nitro-aromatics

Mukesh Pandey, Abhishek Kumar, Sethu Ravichandran, Virinder S. Parmar, Arthur C. Watterson, Jayant Kumar

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Curcumin is well-known for its wide range of physiological actions. It is a fluorescent polyphenol, and its optical properties could be used for sensing chemicals. Major impediment is the aggregation of curcumin in thin film, thereby, reducing the fluorescence quantum yield. Herein, we report the chemo-enzymatic polymerization of curcumin with polydimethylsiloxane (Curcumin-PDMS) to address the aggregation problem. PDMS was applied as the matrix because of its low glass transition temperature, which renders diffusion of analyte molecules in and out of the polymer film. Synthesis of Curcumin-PDMS copolymer is regio-selectively catalyzed by Candida antarctica lipase (Novozym 435) in solvent-less condition under vacuum at 90°C. The optical, thermal and sensing properties of Curcumin-PDMS copolymer are also investigated. Current study presents a generic approach, which could be used to modify other natural products including polyphenols for various applications.

Original languageEnglish (US)
Pages (from-to)399-404
Number of pages6
JournalJournal of Macromolecular Science, Part A: Pure and Applied Chemistry
Volume51
Issue number5
DOIs
StatePublished - May 4 2014

Fingerprint

Curcumin
Polydimethylsiloxane
Copolymers
Agglomeration
Polyphenols
Candida
Lipases
Quantum yield
Polymer films
Optical properties
Fluorescence
Polymerization
Vacuum
Thin films
Biological Products
Molecules
Lipase
baysilon

Keywords

  • candida antarctica lipase
  • chemo-enzymatic
  • Curcumin
  • sensing

ASJC Scopus subject areas

  • Ceramics and Composites
  • Chemistry(all)
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Chemo-enzymatic synthesis of polydimethylsiloxane curcumin copolymer for detection of nitro-aromatics. / Pandey, Mukesh; Kumar, Abhishek; Ravichandran, Sethu; Parmar, Virinder S.; Watterson, Arthur C.; Kumar, Jayant.

In: Journal of Macromolecular Science, Part A: Pure and Applied Chemistry, Vol. 51, No. 5, 04.05.2014, p. 399-404.

Research output: Contribution to journalArticle

Pandey, Mukesh ; Kumar, Abhishek ; Ravichandran, Sethu ; Parmar, Virinder S. ; Watterson, Arthur C. ; Kumar, Jayant. / Chemo-enzymatic synthesis of polydimethylsiloxane curcumin copolymer for detection of nitro-aromatics. In: Journal of Macromolecular Science, Part A: Pure and Applied Chemistry. 2014 ; Vol. 51, No. 5. pp. 399-404.
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