Chemical exposures and Parkinson's disease: A population-based case-control study

Roberta Frigerio, Kevin R. Sanft, Brandon R. Grossardt, Brett J. Peterson, Alexis Elbaz, James Howard Bower, J. Eric Ahlskog, Mariza De Andrade, Demetrius M. Maraganore, Walter A Rocca

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

The putative association between pesticide exposures and Parkinson's disease (PD) remains controversial. We identified all subjects who developed PD in Olmsted County, Minnesota, from 1976 through 1995, and matched them by age (± 1 year) and sex to general population controls. We assessed exposures to chemical products by means of telephone interview with cases, controls, or their proxies (149 cases; 129 controls). Exposure to pesticides related or unrelated to farming was associated with PD in men (odds ratio, 2.4; 95% confidence interval, 1.1-5.4; P = 0.04). The association remained significant after adjustment for education or smoking. Analyses for the other six categories of industrial and household chemicals were all nonsignificant. This population-based study suggests a link between pesticides use and PD that is restricted to men. Pesticides may interact with other genetic or nongenetic factors that are different in men and women.

Original languageEnglish (US)
Pages (from-to)1688-1692
Number of pages5
JournalMovement Disorders
Volume21
Issue number10
DOIs
StatePublished - Oct 2006

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Pesticides
Parkinson Disease
Case-Control Studies
Population
Population Control
Proxy
Agriculture
Smoking
Odds Ratio
Confidence Intervals
Interviews
Education

Keywords

  • Case-control study
  • Chemical exposures
  • Parkinson's disease
  • Pesticides
  • Sex differences

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Chemical exposures and Parkinson's disease : A population-based case-control study. / Frigerio, Roberta; Sanft, Kevin R.; Grossardt, Brandon R.; Peterson, Brett J.; Elbaz, Alexis; Bower, James Howard; Ahlskog, J. Eric; De Andrade, Mariza; Maraganore, Demetrius M.; Rocca, Walter A.

In: Movement Disorders, Vol. 21, No. 10, 10.2006, p. 1688-1692.

Research output: Contribution to journalArticle

Frigerio, R, Sanft, KR, Grossardt, BR, Peterson, BJ, Elbaz, A, Bower, JH, Ahlskog, JE, De Andrade, M, Maraganore, DM & Rocca, WA 2006, 'Chemical exposures and Parkinson's disease: A population-based case-control study', Movement Disorders, vol. 21, no. 10, pp. 1688-1692. https://doi.org/10.1002/mds.21009
Frigerio R, Sanft KR, Grossardt BR, Peterson BJ, Elbaz A, Bower JH et al. Chemical exposures and Parkinson's disease: A population-based case-control study. Movement Disorders. 2006 Oct;21(10):1688-1692. https://doi.org/10.1002/mds.21009
Frigerio, Roberta ; Sanft, Kevin R. ; Grossardt, Brandon R. ; Peterson, Brett J. ; Elbaz, Alexis ; Bower, James Howard ; Ahlskog, J. Eric ; De Andrade, Mariza ; Maraganore, Demetrius M. ; Rocca, Walter A. / Chemical exposures and Parkinson's disease : A population-based case-control study. In: Movement Disorders. 2006 ; Vol. 21, No. 10. pp. 1688-1692.
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