TY - JOUR
T1 - Chemical composition, antioxidant, anti-inflammatory and antiproliferative activities of the essential oil of Cymbopogon nardus, a plant used in traditional medicine
AU - Bayala, Bagora
AU - Coulibaly, Ahmed Y.
AU - Djigma, Florencia W.
AU - Nagalo, Bolni Marius
AU - Baron, Silvère
AU - Figueredo, Gilles
AU - Lobaccaro, Jean Marc A.
AU - Simpore, Jacques
N1 - Funding Information:
Funding :Part of this study was supported from Ambassade de France au Burkina Faso (Grant Stage SSHN n°948600C) and Ministère de l’Enseignement Supérieur, de la Recherche Scientifique et de l’Innovation (MESRSI) of Burkina Faso for BB, Région Auvergne-Rhône Alpes, Fond Européen de Développement Régional (FEDER), Plan National de Recherche sur les Perturbateurs Endocriniens (13-MRES-PNRPE-1-CVS043), and Plan-Cancer 2016 for SB and JMAL. The funders had no role in the study design, data collection or analysis, decision to publish, or in the preparation of the manuscript.
Publisher Copyright:
© 2020 Bagora Bayala et al., published by De Gruyter.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Natural products commonly used in traditional medicine, such as essential oils (EOs), are attractive sources for the development of molecules with anti-proliferative activities for future treatment of human cancers, e.g., prostate and cervical cancer. In this study, the chemical composition of the EO from Cymbopogon nardus was characterized, as well as its antioxidativeproperties and anti-inflammatory and antiproliferative activities on LNCaP cells derived from prostate cancer. The chemical composition of the EO was determined by GC/FID and GC/MS analyses. The antioxidative properties were assessed using DPPH radical scavenging assay and ABTS+•radical cation decolorization assay, and the anti-inflammatory capacity was determined by the inhibition of the lipoxygenase activity. Antiproliferative activity was evaluated by MTT assay. Collectively, our data show that the major constituents of C. nardus EO are citronellal (33.06 %), geraniol (28.40 %), nerol (10.94 %), elemol (5.25 %) and delta-elemene (4.09 %). C. nardus EO shows modest antioxidant and anti-inflammatory activity compared to the standard galic acid. C. nardus EO exhibits the best antiproliferative activity on the prostate cancer cell line LNCaP with an IC50 of 58.0 ± 7.9 μg/mL, acting through the induction of the cell cycle arrest. This study has determined that C. nardus EO efficiently triggers cytotoxicity and pens a new field of investigation regarding the putative use of this EO in vivo.
AB - Natural products commonly used in traditional medicine, such as essential oils (EOs), are attractive sources for the development of molecules with anti-proliferative activities for future treatment of human cancers, e.g., prostate and cervical cancer. In this study, the chemical composition of the EO from Cymbopogon nardus was characterized, as well as its antioxidativeproperties and anti-inflammatory and antiproliferative activities on LNCaP cells derived from prostate cancer. The chemical composition of the EO was determined by GC/FID and GC/MS analyses. The antioxidative properties were assessed using DPPH radical scavenging assay and ABTS+•radical cation decolorization assay, and the anti-inflammatory capacity was determined by the inhibition of the lipoxygenase activity. Antiproliferative activity was evaluated by MTT assay. Collectively, our data show that the major constituents of C. nardus EO are citronellal (33.06 %), geraniol (28.40 %), nerol (10.94 %), elemol (5.25 %) and delta-elemene (4.09 %). C. nardus EO shows modest antioxidant and anti-inflammatory activity compared to the standard galic acid. C. nardus EO exhibits the best antiproliferative activity on the prostate cancer cell line LNCaP with an IC50 of 58.0 ± 7.9 μg/mL, acting through the induction of the cell cycle arrest. This study has determined that C. nardus EO efficiently triggers cytotoxicity and pens a new field of investigation regarding the putative use of this EO in vivo.
KW - Cymbopogon nardus
KW - anti-inflammatory
KW - antioxidant
KW - antiproliferative
KW - essential oil
KW - gas chromatography
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U2 - 10.1515/bmc-2020-0007
DO - 10.1515/bmc-2020-0007
M3 - Article
C2 - 32304294
AN - SCOPUS:85083755642
VL - 11
SP - 86
EP - 96
JO - Biomolecular Concepts
JF - Biomolecular Concepts
SN - 1868-5021
IS - 1
ER -