cHCC-CCA: Consensus terminology for primary liver carcinomas with both hepatocytic and cholangiocytic differentation

Elizabeth Brunt, Shinichi Aishima, Pierre Alain Clavien, Kathryn Fowler, Zachary Goodman, Gregory James Gores, Annette Gouw, Alex Kagen, David Klimstra, Mina Komuta, Fukuo Kondo, Rebecca Miksad, Masayuki Nakano, Yasuni Nakanuma, Irene Ng, Valerie Paradis, Young Nyun Park, Alberto Quaglia, Massimo Roncalli, Tania RoskamsMichiie Sakamoto, Romil Saxena, Christine Sempoux, Claude Sirlin, Ashley Stueck, Swan Thung, W. M.S. Tsui, Xin Wei Wang, Aileen Wee, Hirohisa Yano, Matthew Yeh, Yoh Zen, Jessica Zucman-Rossi, Neil Theise

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Primary liver carcinomas with both hepatocytic and cholangiocytic differentiation have been referred to as "combined (or mixed) hepatocellular-cholangiocarcinoma." These tumors, although described over 100 years ago, have attracted greater attention recently because of interest in possible stem cell origin and perhaps because of greater frequency and clinical recognition. Currently, because of a lack of common terminology in the literature, effective treatment and predictable outcome data have been challenging to accrue. This article represents a consensus document from an international community of pathologists, radiologists, and clinicians who have studied and reported on these tumors and recommends a working terminology for diagnostic and research approaches for further study and evaluation. Conclusion: It is recommended that diagnosis is based on routine histopathology with hematoxylin and eosin (H&E); immunostains are supportive, but not essential for diagnosis.

Original languageEnglish (US)
JournalHepatology
DOIs
StateAccepted/In press - Jan 1 2018

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Terminology
Carcinoma
Cholangiocarcinoma
Liver
Hematoxylin
Eosine Yellowish-(YS)
Neoplasms
Stem Cells
Research
Pathologists
Radiologists

ASJC Scopus subject areas

  • Hepatology

Cite this

cHCC-CCA : Consensus terminology for primary liver carcinomas with both hepatocytic and cholangiocytic differentation. / Brunt, Elizabeth; Aishima, Shinichi; Clavien, Pierre Alain; Fowler, Kathryn; Goodman, Zachary; Gores, Gregory James; Gouw, Annette; Kagen, Alex; Klimstra, David; Komuta, Mina; Kondo, Fukuo; Miksad, Rebecca; Nakano, Masayuki; Nakanuma, Yasuni; Ng, Irene; Paradis, Valerie; Nyun Park, Young; Quaglia, Alberto; Roncalli, Massimo; Roskams, Tania; Sakamoto, Michiie; Saxena, Romil; Sempoux, Christine; Sirlin, Claude; Stueck, Ashley; Thung, Swan; Tsui, W. M.S.; Wang, Xin Wei; Wee, Aileen; Yano, Hirohisa; Yeh, Matthew; Zen, Yoh; Zucman-Rossi, Jessica; Theise, Neil.

In: Hepatology, 01.01.2018.

Research output: Contribution to journalArticle

Brunt, E, Aishima, S, Clavien, PA, Fowler, K, Goodman, Z, Gores, GJ, Gouw, A, Kagen, A, Klimstra, D, Komuta, M, Kondo, F, Miksad, R, Nakano, M, Nakanuma, Y, Ng, I, Paradis, V, Nyun Park, Y, Quaglia, A, Roncalli, M, Roskams, T, Sakamoto, M, Saxena, R, Sempoux, C, Sirlin, C, Stueck, A, Thung, S, Tsui, WMS, Wang, XW, Wee, A, Yano, H, Yeh, M, Zen, Y, Zucman-Rossi, J & Theise, N 2018, 'cHCC-CCA: Consensus terminology for primary liver carcinomas with both hepatocytic and cholangiocytic differentation', Hepatology. https://doi.org/10.1002/hep.29789
Brunt, Elizabeth ; Aishima, Shinichi ; Clavien, Pierre Alain ; Fowler, Kathryn ; Goodman, Zachary ; Gores, Gregory James ; Gouw, Annette ; Kagen, Alex ; Klimstra, David ; Komuta, Mina ; Kondo, Fukuo ; Miksad, Rebecca ; Nakano, Masayuki ; Nakanuma, Yasuni ; Ng, Irene ; Paradis, Valerie ; Nyun Park, Young ; Quaglia, Alberto ; Roncalli, Massimo ; Roskams, Tania ; Sakamoto, Michiie ; Saxena, Romil ; Sempoux, Christine ; Sirlin, Claude ; Stueck, Ashley ; Thung, Swan ; Tsui, W. M.S. ; Wang, Xin Wei ; Wee, Aileen ; Yano, Hirohisa ; Yeh, Matthew ; Zen, Yoh ; Zucman-Rossi, Jessica ; Theise, Neil. / cHCC-CCA : Consensus terminology for primary liver carcinomas with both hepatocytic and cholangiocytic differentation. In: Hepatology. 2018.
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AU - Aishima, Shinichi

AU - Clavien, Pierre Alain

AU - Fowler, Kathryn

AU - Goodman, Zachary

AU - Gores, Gregory James

AU - Gouw, Annette

AU - Kagen, Alex

AU - Klimstra, David

AU - Komuta, Mina

AU - Kondo, Fukuo

AU - Miksad, Rebecca

AU - Nakano, Masayuki

AU - Nakanuma, Yasuni

AU - Ng, Irene

AU - Paradis, Valerie

AU - Nyun Park, Young

AU - Quaglia, Alberto

AU - Roncalli, Massimo

AU - Roskams, Tania

AU - Sakamoto, Michiie

AU - Saxena, Romil

AU - Sempoux, Christine

AU - Sirlin, Claude

AU - Stueck, Ashley

AU - Thung, Swan

AU - Tsui, W. M.S.

AU - Wang, Xin Wei

AU - Wee, Aileen

AU - Yano, Hirohisa

AU - Yeh, Matthew

AU - Zen, Yoh

AU - Zucman-Rossi, Jessica

AU - Theise, Neil

PY - 2018/1/1

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