Characterizing white matter tract degeneration in syndromic variants of Alzheimer's disease: A diffusion tensor imaging study

Ajay Madhavan, Christopher Schwarz, Joseph R. Duffy, Edythe A. Strand, Mary Margaret Machulda, Daniel Drubach, Kejal M Kantarci, Scott A. Przybelski, Robert I. Reid, Matthew L. Senjem, Jeffrey L. Gunter, Liana G. Apostolova, Val Lowe, Ronald Carl Petersen, Clifford R Jr. Jack, Keith Anthony Josephs, Jennifer Lynn Whitwell

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Different clinical syndromes can arise from Alzheimer's disease (AD) neuropathology, including dementia of the Alzheimer's type (DAT), logopenic primary progressive aphasia (lvPPA), and posterior cortical atrophy (PCA). Objective: To assess similarities and differences in patterns of white matter tract degeneration across these syndromic variants of AD. Methods: Sixty-four subjects (22 DAT, 24 lvPPA, and 18 PCA) that had diffusion tensor imaging and showed amyloid deposition on PET were assessed in this case-control study. A whole-brain voxel-based analysis was performed to assess differences in fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity across groups. Results: All three groups showed overlapping diffusion abnormalities in a network of tracts, including fornix, corpus callosum, posterior thalamic radiations, superior longitudinal fasciculus, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, and uncinate fasciculus. Subtle regional differences were also observed across groups, with DAT particularly associated with degeneration of fornix and cingulum, lvPPA with left inferior fronto-occipital fasciculus and uncinate fasciculus, and PCA with posterior thalamic radiations, superior longitudinal fasciculus, posterior cingulate, and splenium of the corpus callosum. Conclusion: These findings show that while each AD phenotype is associated with degeneration of a specific structural network of white matter tracts, striking spatial overlap exists among the three network patterns that may be related to AD pathology.

Original languageEnglish (US)
Pages (from-to)633-643
Number of pages11
JournalJournal of Alzheimer's Disease
Volume49
Issue number3
DOIs
StatePublished - 2016

Fingerprint

Diffusion Tensor Imaging
Alzheimer Disease
Atrophy
Corpus Callosum
Primary Progressive Aphasia
Radiation
Gyrus Cinguli
Anisotropy
White Matter
Amyloid
Case-Control Studies
Pathology
Phenotype
Brain

Keywords

  • Alzheimer's disease
  • Diffusion tensor imaging
  • Logopenic
  • Posterior cortical atrophy
  • White matter

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

Cite this

Characterizing white matter tract degeneration in syndromic variants of Alzheimer's disease : A diffusion tensor imaging study. / Madhavan, Ajay; Schwarz, Christopher; Duffy, Joseph R.; Strand, Edythe A.; Machulda, Mary Margaret; Drubach, Daniel; Kantarci, Kejal M; Przybelski, Scott A.; Reid, Robert I.; Senjem, Matthew L.; Gunter, Jeffrey L.; Apostolova, Liana G.; Lowe, Val; Petersen, Ronald Carl; Jack, Clifford R Jr.; Josephs, Keith Anthony; Whitwell, Jennifer Lynn.

In: Journal of Alzheimer's Disease, Vol. 49, No. 3, 2016, p. 633-643.

Research output: Contribution to journalArticle

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abstract = "Background: Different clinical syndromes can arise from Alzheimer's disease (AD) neuropathology, including dementia of the Alzheimer's type (DAT), logopenic primary progressive aphasia (lvPPA), and posterior cortical atrophy (PCA). Objective: To assess similarities and differences in patterns of white matter tract degeneration across these syndromic variants of AD. Methods: Sixty-four subjects (22 DAT, 24 lvPPA, and 18 PCA) that had diffusion tensor imaging and showed amyloid deposition on PET were assessed in this case-control study. A whole-brain voxel-based analysis was performed to assess differences in fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity across groups. Results: All three groups showed overlapping diffusion abnormalities in a network of tracts, including fornix, corpus callosum, posterior thalamic radiations, superior longitudinal fasciculus, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, and uncinate fasciculus. Subtle regional differences were also observed across groups, with DAT particularly associated with degeneration of fornix and cingulum, lvPPA with left inferior fronto-occipital fasciculus and uncinate fasciculus, and PCA with posterior thalamic radiations, superior longitudinal fasciculus, posterior cingulate, and splenium of the corpus callosum. Conclusion: These findings show that while each AD phenotype is associated with degeneration of a specific structural network of white matter tracts, striking spatial overlap exists among the three network patterns that may be related to AD pathology.",
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T1 - Characterizing white matter tract degeneration in syndromic variants of Alzheimer's disease

T2 - A diffusion tensor imaging study

AU - Madhavan, Ajay

AU - Schwarz, Christopher

AU - Duffy, Joseph R.

AU - Strand, Edythe A.

AU - Machulda, Mary Margaret

AU - Drubach, Daniel

AU - Kantarci, Kejal M

AU - Przybelski, Scott A.

AU - Reid, Robert I.

AU - Senjem, Matthew L.

AU - Gunter, Jeffrey L.

AU - Apostolova, Liana G.

AU - Lowe, Val

AU - Petersen, Ronald Carl

AU - Jack, Clifford R Jr.

AU - Josephs, Keith Anthony

AU - Whitwell, Jennifer Lynn

PY - 2016

Y1 - 2016

N2 - Background: Different clinical syndromes can arise from Alzheimer's disease (AD) neuropathology, including dementia of the Alzheimer's type (DAT), logopenic primary progressive aphasia (lvPPA), and posterior cortical atrophy (PCA). Objective: To assess similarities and differences in patterns of white matter tract degeneration across these syndromic variants of AD. Methods: Sixty-four subjects (22 DAT, 24 lvPPA, and 18 PCA) that had diffusion tensor imaging and showed amyloid deposition on PET were assessed in this case-control study. A whole-brain voxel-based analysis was performed to assess differences in fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity across groups. Results: All three groups showed overlapping diffusion abnormalities in a network of tracts, including fornix, corpus callosum, posterior thalamic radiations, superior longitudinal fasciculus, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, and uncinate fasciculus. Subtle regional differences were also observed across groups, with DAT particularly associated with degeneration of fornix and cingulum, lvPPA with left inferior fronto-occipital fasciculus and uncinate fasciculus, and PCA with posterior thalamic radiations, superior longitudinal fasciculus, posterior cingulate, and splenium of the corpus callosum. Conclusion: These findings show that while each AD phenotype is associated with degeneration of a specific structural network of white matter tracts, striking spatial overlap exists among the three network patterns that may be related to AD pathology.

AB - Background: Different clinical syndromes can arise from Alzheimer's disease (AD) neuropathology, including dementia of the Alzheimer's type (DAT), logopenic primary progressive aphasia (lvPPA), and posterior cortical atrophy (PCA). Objective: To assess similarities and differences in patterns of white matter tract degeneration across these syndromic variants of AD. Methods: Sixty-four subjects (22 DAT, 24 lvPPA, and 18 PCA) that had diffusion tensor imaging and showed amyloid deposition on PET were assessed in this case-control study. A whole-brain voxel-based analysis was performed to assess differences in fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity across groups. Results: All three groups showed overlapping diffusion abnormalities in a network of tracts, including fornix, corpus callosum, posterior thalamic radiations, superior longitudinal fasciculus, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, and uncinate fasciculus. Subtle regional differences were also observed across groups, with DAT particularly associated with degeneration of fornix and cingulum, lvPPA with left inferior fronto-occipital fasciculus and uncinate fasciculus, and PCA with posterior thalamic radiations, superior longitudinal fasciculus, posterior cingulate, and splenium of the corpus callosum. Conclusion: These findings show that while each AD phenotype is associated with degeneration of a specific structural network of white matter tracts, striking spatial overlap exists among the three network patterns that may be related to AD pathology.

KW - Alzheimer's disease

KW - Diffusion tensor imaging

KW - Logopenic

KW - Posterior cortical atrophy

KW - White matter

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