Characterizing the epidemiology of perioperative transfusion-associated circulatory overload

Leanne Clifford, Qing Jia, Hemang Yadav, Arun Subramanian, Gregory A. Wilson, Sean P. Murphy, Jyotishman Pathak, Darrell R. Schroeder, Mark H. Ereth, Daryl J Kor

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Abstract

BACKGROUND: Transfusion-associated circulatory overload (TACO) is a leading cause of transfusion-related fatalities, but its incidence and associated patient and transfusion characteristics are poorly understood. To inform surgical transfusion practice and to begin mitigating perioperative TACO, the authors aimed to define its epidemiology.

METHODS: In this retrospective cohort study, the medical records of adult patients undergoing noncardiac surgery with general anesthesia during 2004 or 2011 and receiving intraoperative transfusions were screened using an electronic algorithm for identification of TACO. Those patients who were screened as high probability for TACO underwent rigorous manual review. Univariate and multivariate analyses evaluated associations between patient and transfusion characteristics with TACO rates in a before-and-after study design.

RESULTS: A total of 2,162 and 1,908 patients met study criteria for 2004 and 2011, respectively. The incidence of TACO was 5.5% (119 of 2,162) in 2004 versus 3.0% (57 of 1,908) in 2011 (P < 0.001), with comparable rates for men (4.8% [98 of 2,023]) and women (3.8% [78 of 2,047]) (P = 0.09). Overall, vascular (12.1% [60 of 497]), transplant (8.8% [17 of 193]), and thoracic surgeries (7.2% [10 of 138]) carried the highest TACO rates. Obstetric and gynecologic patients had the lowest rate (1.4% [4 of 295]). The incidence of TACO increased with volume transfused, advancing age, and total intraoperative fluid balance (all P < 0.001).

CONCLUSIONS: The incidence of perioperative TACO is similar to previous estimates in nonsurgical populations. There was a reduction in TACO rate between 2004 and 2011, with incidence patterns remaining comparable in subgroup analyses. Future efforts exploring risk factors for TACO may guide preventive or therapeutic interventions, helping to further mitigate this transfusion complication.

Original languageEnglish (US)
Pages (from-to)21-28
Number of pages8
JournalAnesthesiology
Volume122
Issue number1
DOIs
StatePublished - Jan 1 2015

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Epidemiology
Incidence
Water-Electrolyte Balance
General Anesthesia
Thoracic Surgery
Obstetrics
Medical Records
Blood Vessels
Cohort Studies
Multivariate Analysis
Retrospective Studies
Transplants
Population
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

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Characterizing the epidemiology of perioperative transfusion-associated circulatory overload. / Clifford, Leanne; Jia, Qing; Yadav, Hemang; Subramanian, Arun; Wilson, Gregory A.; Murphy, Sean P.; Pathak, Jyotishman; Schroeder, Darrell R.; Ereth, Mark H.; Kor, Daryl J.

In: Anesthesiology, Vol. 122, No. 1, 01.01.2015, p. 21-28.

Research output: Contribution to journalArticle

Clifford, L, Jia, Q, Yadav, H, Subramanian, A, Wilson, GA, Murphy, SP, Pathak, J, Schroeder, DR, Ereth, MH & Kor, DJ 2015, 'Characterizing the epidemiology of perioperative transfusion-associated circulatory overload', Anesthesiology, vol. 122, no. 1, pp. 21-28. https://doi.org/10.1097/ALN.0000000000000513
Clifford L, Jia Q, Yadav H, Subramanian A, Wilson GA, Murphy SP et al. Characterizing the epidemiology of perioperative transfusion-associated circulatory overload. Anesthesiology. 2015 Jan 1;122(1):21-28. https://doi.org/10.1097/ALN.0000000000000513
Clifford, Leanne ; Jia, Qing ; Yadav, Hemang ; Subramanian, Arun ; Wilson, Gregory A. ; Murphy, Sean P. ; Pathak, Jyotishman ; Schroeder, Darrell R. ; Ereth, Mark H. ; Kor, Daryl J. / Characterizing the epidemiology of perioperative transfusion-associated circulatory overload. In: Anesthesiology. 2015 ; Vol. 122, No. 1. pp. 21-28.
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abstract = "BACKGROUND: Transfusion-associated circulatory overload (TACO) is a leading cause of transfusion-related fatalities, but its incidence and associated patient and transfusion characteristics are poorly understood. To inform surgical transfusion practice and to begin mitigating perioperative TACO, the authors aimed to define its epidemiology.METHODS: In this retrospective cohort study, the medical records of adult patients undergoing noncardiac surgery with general anesthesia during 2004 or 2011 and receiving intraoperative transfusions were screened using an electronic algorithm for identification of TACO. Those patients who were screened as high probability for TACO underwent rigorous manual review. Univariate and multivariate analyses evaluated associations between patient and transfusion characteristics with TACO rates in a before-and-after study design.RESULTS: A total of 2,162 and 1,908 patients met study criteria for 2004 and 2011, respectively. The incidence of TACO was 5.5{\%} (119 of 2,162) in 2004 versus 3.0{\%} (57 of 1,908) in 2011 (P < 0.001), with comparable rates for men (4.8{\%} [98 of 2,023]) and women (3.8{\%} [78 of 2,047]) (P = 0.09). Overall, vascular (12.1{\%} [60 of 497]), transplant (8.8{\%} [17 of 193]), and thoracic surgeries (7.2{\%} [10 of 138]) carried the highest TACO rates. Obstetric and gynecologic patients had the lowest rate (1.4{\%} [4 of 295]). The incidence of TACO increased with volume transfused, advancing age, and total intraoperative fluid balance (all P < 0.001).CONCLUSIONS: The incidence of perioperative TACO is similar to previous estimates in nonsurgical populations. There was a reduction in TACO rate between 2004 and 2011, with incidence patterns remaining comparable in subgroup analyses. Future efforts exploring risk factors for TACO may guide preventive or therapeutic interventions, helping to further mitigate this transfusion complication.",
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AU - Clifford, Leanne

AU - Jia, Qing

AU - Yadav, Hemang

AU - Subramanian, Arun

AU - Wilson, Gregory A.

AU - Murphy, Sean P.

AU - Pathak, Jyotishman

AU - Schroeder, Darrell R.

AU - Ereth, Mark H.

AU - Kor, Daryl J

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N2 - BACKGROUND: Transfusion-associated circulatory overload (TACO) is a leading cause of transfusion-related fatalities, but its incidence and associated patient and transfusion characteristics are poorly understood. To inform surgical transfusion practice and to begin mitigating perioperative TACO, the authors aimed to define its epidemiology.METHODS: In this retrospective cohort study, the medical records of adult patients undergoing noncardiac surgery with general anesthesia during 2004 or 2011 and receiving intraoperative transfusions were screened using an electronic algorithm for identification of TACO. Those patients who were screened as high probability for TACO underwent rigorous manual review. Univariate and multivariate analyses evaluated associations between patient and transfusion characteristics with TACO rates in a before-and-after study design.RESULTS: A total of 2,162 and 1,908 patients met study criteria for 2004 and 2011, respectively. The incidence of TACO was 5.5% (119 of 2,162) in 2004 versus 3.0% (57 of 1,908) in 2011 (P < 0.001), with comparable rates for men (4.8% [98 of 2,023]) and women (3.8% [78 of 2,047]) (P = 0.09). Overall, vascular (12.1% [60 of 497]), transplant (8.8% [17 of 193]), and thoracic surgeries (7.2% [10 of 138]) carried the highest TACO rates. Obstetric and gynecologic patients had the lowest rate (1.4% [4 of 295]). The incidence of TACO increased with volume transfused, advancing age, and total intraoperative fluid balance (all P < 0.001).CONCLUSIONS: The incidence of perioperative TACO is similar to previous estimates in nonsurgical populations. There was a reduction in TACO rate between 2004 and 2011, with incidence patterns remaining comparable in subgroup analyses. Future efforts exploring risk factors for TACO may guide preventive or therapeutic interventions, helping to further mitigate this transfusion complication.

AB - BACKGROUND: Transfusion-associated circulatory overload (TACO) is a leading cause of transfusion-related fatalities, but its incidence and associated patient and transfusion characteristics are poorly understood. To inform surgical transfusion practice and to begin mitigating perioperative TACO, the authors aimed to define its epidemiology.METHODS: In this retrospective cohort study, the medical records of adult patients undergoing noncardiac surgery with general anesthesia during 2004 or 2011 and receiving intraoperative transfusions were screened using an electronic algorithm for identification of TACO. Those patients who were screened as high probability for TACO underwent rigorous manual review. Univariate and multivariate analyses evaluated associations between patient and transfusion characteristics with TACO rates in a before-and-after study design.RESULTS: A total of 2,162 and 1,908 patients met study criteria for 2004 and 2011, respectively. The incidence of TACO was 5.5% (119 of 2,162) in 2004 versus 3.0% (57 of 1,908) in 2011 (P < 0.001), with comparable rates for men (4.8% [98 of 2,023]) and women (3.8% [78 of 2,047]) (P = 0.09). Overall, vascular (12.1% [60 of 497]), transplant (8.8% [17 of 193]), and thoracic surgeries (7.2% [10 of 138]) carried the highest TACO rates. Obstetric and gynecologic patients had the lowest rate (1.4% [4 of 295]). The incidence of TACO increased with volume transfused, advancing age, and total intraoperative fluid balance (all P < 0.001).CONCLUSIONS: The incidence of perioperative TACO is similar to previous estimates in nonsurgical populations. There was a reduction in TACO rate between 2004 and 2011, with incidence patterns remaining comparable in subgroup analyses. Future efforts exploring risk factors for TACO may guide preventive or therapeutic interventions, helping to further mitigate this transfusion complication.

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