Characterizing mechanical properties of human blood clots using optical coherence elastography

Hsiao Chuan Liu; Mehdi Abbasi; Yong Hong Ding; Tuhin Roy; Margherita Capriotti; Murthy Guddati; Ramanathan Kadirvel; David F. Kallmes; Waleed Brinjikji; Matthew W. Urban

doi:10.1117/12.2577975

Characterizing mechanical properties of human blood clots using optical coherence elastography

Hsiao Chuan Liu, Mehdi Abbasi, Yong Hong Ding, Tuhin Roy, Margherita Capriotti, Murthy Guddati, Ramanathan Kadirvel, David F. Kallmes, Waleed Brinjikji, Matthew W. Urban

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Thromboembolism in the cerebrovasculature can cause high morbidity and mortality. Embolectomy is one of the emergency procedures performed to remove emboli; however, the approach such as aspiration or stent retriever are empirically selected. An inappropriate selection of approach can influence the success rate during embolectomy and affect levels of brain damage. Therefore, understanding the composition of clots and their mechanical properties can lead to an appropriate treatment strategy for physicians. In this study, we investigated how the composition of human clots can affect their mechanical properties as quantified using acoustic radiation force optical coherence elastography (ARF-OCE) in a non-contact manner. Five red blood cells (RBCs) concentrations were fabricated from fibrin rich (21% RBC) to RBC rich (95% RBC). A 7.5 MHz highly focused transducer was used to provide acoustic radiation force exerted on the surface of the clots and an optical coherence tomography system was used to measure the wave propagation. The study showed that the trend of the wave velocities decreased with the RBC concentration increased. The study demonstrated that ARF-OCE could be a promising tool to quantify the mechanical properties of clots to inform treatment strategy for clinical interventionalists.

Original language	English (US)
Title of host publication	Optical Elastography and Tissue Biomechanics VIII
Editors	Kirill V. Larin, Giuliano Scarcelli
Publisher	SPIE
ISBN (Electronic)	9781510641259
DOIs	https://doi.org/10.1117/12.2577975
State	Published - 2021
Event	Optical Elastography and Tissue Biomechanics VIII 2021 - Virtual, Online, United States Duration: Mar 6 2021 → Mar 11 2021

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	11645
ISSN (Print)	1605-7422

Conference

Conference	Optical Elastography and Tissue Biomechanics VIII 2021
Country/Territory	United States
City	Virtual, Online
Period	3/6/21 → 3/11/21

Keywords

Acoustic radiation force
Clot
Mechanical property
Optical coherence elastography
Red blood cell
Shear wave elastography
Stroke
Ultrasound

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Biomaterials
Radiology Nuclear Medicine and imaging

Access to Document

10.1117/12.2577975

Cite this

Liu, H. C., Abbasi, M., Ding, Y. H., Roy, T., Capriotti, M., Guddati, M., Kadirvel, R., Kallmes, D. F., Brinjikji, W., & Urban, M. W. (2021). Characterizing mechanical properties of human blood clots using optical coherence elastography. In K. V. Larin, & G. Scarcelli (Eds.), Optical Elastography and Tissue Biomechanics VIII [116450K] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11645). SPIE. https://doi.org/10.1117/12.2577975

Characterizing mechanical properties of human blood clots using optical coherence elastography. / Liu, Hsiao Chuan; Abbasi, Mehdi; Ding, Yong Hong et al.

Optical Elastography and Tissue Biomechanics VIII. ed. / Kirill V. Larin; Giuliano Scarcelli. SPIE, 2021. 116450K (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11645).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Liu, HC, Abbasi, M, Ding, YH, Roy, T, Capriotti, M, Guddati, M, Kadirvel, R , Kallmes, DF , Brinjikji, W & Urban, MW 2021, Characterizing mechanical properties of human blood clots using optical coherence elastography. in KV Larin & G Scarcelli (eds), Optical Elastography and Tissue Biomechanics VIII., 116450K, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11645, SPIE, Optical Elastography and Tissue Biomechanics VIII 2021, Virtual, Online, United States, 3/6/21. https://doi.org/10.1117/12.2577975

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abstract = "Thromboembolism in the cerebrovasculature can cause high morbidity and mortality. Embolectomy is one of the emergency procedures performed to remove emboli; however, the approach such as aspiration or stent retriever are empirically selected. An inappropriate selection of approach can influence the success rate during embolectomy and affect levels of brain damage. Therefore, understanding the composition of clots and their mechanical properties can lead to an appropriate treatment strategy for physicians. In this study, we investigated how the composition of human clots can affect their mechanical properties as quantified using acoustic radiation force optical coherence elastography (ARF-OCE) in a non-contact manner. Five red blood cells (RBCs) concentrations were fabricated from fibrin rich (21% RBC) to RBC rich (95% RBC). A 7.5 MHz highly focused transducer was used to provide acoustic radiation force exerted on the surface of the clots and an optical coherence tomography system was used to measure the wave propagation. The study showed that the trend of the wave velocities decreased with the RBC concentration increased. The study demonstrated that ARF-OCE could be a promising tool to quantify the mechanical properties of clots to inform treatment strategy for clinical interventionalists.",

keywords = "Acoustic radiation force, Clot, Mechanical property, Optical coherence elastography, Red blood cell, Shear wave elastography, Stroke, Ultrasound",

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AU - Liu, Hsiao Chuan

AU - Abbasi, Mehdi

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AU - Capriotti, Margherita

AU - Guddati, Murthy

AU - Kadirvel, Ramanathan

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AB - Thromboembolism in the cerebrovasculature can cause high morbidity and mortality. Embolectomy is one of the emergency procedures performed to remove emboli; however, the approach such as aspiration or stent retriever are empirically selected. An inappropriate selection of approach can influence the success rate during embolectomy and affect levels of brain damage. Therefore, understanding the composition of clots and their mechanical properties can lead to an appropriate treatment strategy for physicians. In this study, we investigated how the composition of human clots can affect their mechanical properties as quantified using acoustic radiation force optical coherence elastography (ARF-OCE) in a non-contact manner. Five red blood cells (RBCs) concentrations were fabricated from fibrin rich (21% RBC) to RBC rich (95% RBC). A 7.5 MHz highly focused transducer was used to provide acoustic radiation force exerted on the surface of the clots and an optical coherence tomography system was used to measure the wave propagation. The study showed that the trend of the wave velocities decreased with the RBC concentration increased. The study demonstrated that ARF-OCE could be a promising tool to quantify the mechanical properties of clots to inform treatment strategy for clinical interventionalists.

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ER -

Characterizing mechanical properties of human blood clots using optical coherence elastography

Abstract

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Keywords

ASJC Scopus subject areas

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