Characterizing axillary web syndrome

Ultrasonographic efficacy

L. A. Koehler, D. W. Hunter, Tufia C Haddad, A. H. Blaes, A. T. Hirsch, P. M. Ludewig

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The aim of this study was to determine if ultrasound could successfully characterize axillary web syndrome (AWS) and clarify the pathophysiologic basis of AWS as a vascular or lymphatic abnormality, or an abnormal tissue structure. This prospective study evaluated women who developed AWS following breast cancer surgery. Using an 18MHz ultrasound transducer, images were taken of the AWS cord and compared to mirror images on the contralateral side. A blinded radiologist assessed the ultrasound characteristics of and structural changes in the skin and subcutaneous tissue and formulated an opinion as to the side in which AWS was located. Seventeen subjects participated in the study. No structure or abnormality consistent with AWS could be identified by ultrasound. There were no statistical differences between the ipsilateral and contralateral side in skin thickness; subcutaneous reflector thickness, number or disorganization; or subcutaneous tissue echodensity (p>0.05). The radiologist correctly identified the side with AWS in 12 of 17 subjects (=0.41). A distinct ultrasonographic structure or abnormality could not be identified in subjects with AWS using 18MHz ultrasound. The inability to identify a specific structure excludes the possibility that AWS is associated with vein thrombosis or a fascial abnormality, and supports the theory that AWS may be pathology that is not visible with 18MHz ultrasound, such as microlymphatic stasis or binding of fibrin or other proteins in the interstitial space.

Original languageEnglish (US)
Pages (from-to)156-163
Number of pages8
JournalLymphology
Volume47
Issue number4
StatePublished - Dec 1 2014

Fingerprint

Subcutaneous Tissue
Lymphatic Abnormalities
Skin
Fibrin
Transducers
Blood Vessels
Veins
Thrombosis
Prospective Studies
Pathology
Breast Neoplasms
Proteins
Radiologists

Keywords

  • Axillary web syndrome
  • Breast cancer
  • Cording
  • Lymphatics
  • Mondor's syndrome
  • Ultrasound

ASJC Scopus subject areas

  • Immunology and Allergy
  • Hematology
  • Medicine(all)

Cite this

Koehler, L. A., Hunter, D. W., Haddad, T. C., Blaes, A. H., Hirsch, A. T., & Ludewig, P. M. (2014). Characterizing axillary web syndrome: Ultrasonographic efficacy. Lymphology, 47(4), 156-163.

Characterizing axillary web syndrome : Ultrasonographic efficacy. / Koehler, L. A.; Hunter, D. W.; Haddad, Tufia C; Blaes, A. H.; Hirsch, A. T.; Ludewig, P. M.

In: Lymphology, Vol. 47, No. 4, 01.12.2014, p. 156-163.

Research output: Contribution to journalArticle

Koehler, LA, Hunter, DW, Haddad, TC, Blaes, AH, Hirsch, AT & Ludewig, PM 2014, 'Characterizing axillary web syndrome: Ultrasonographic efficacy', Lymphology, vol. 47, no. 4, pp. 156-163.
Koehler LA, Hunter DW, Haddad TC, Blaes AH, Hirsch AT, Ludewig PM. Characterizing axillary web syndrome: Ultrasonographic efficacy. Lymphology. 2014 Dec 1;47(4):156-163.
Koehler, L. A. ; Hunter, D. W. ; Haddad, Tufia C ; Blaes, A. H. ; Hirsch, A. T. ; Ludewig, P. M. / Characterizing axillary web syndrome : Ultrasonographic efficacy. In: Lymphology. 2014 ; Vol. 47, No. 4. pp. 156-163.
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