Characterization of transverse isotropy in compressed tissue mimicking phantoms

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Tissues such as skeletal muscle and kidneys have well-defined structure that affects the measurements of mechanical properties. As an approach to characterize the material properties of these tissues, different groups have assumed that they are transversely isotropic (TI) and measure the shear wave velocity as it varies with angle with respect to the structural architecture of the organ. To refine measurements in these organs, it is desirable to have tissue mimicking phantoms that exhibit similar anisotropic characteristics. Some approaches involve embedding fibers into a material matrix. However, if a homogeneous solid is under compression due to a static stress, an acoustoelastic effect can manifest which makes the measured wave velocities change with the compression stress. We propose to exploit this characteristic to demonstrate that stressed tissue mimicking phantoms can be characterized as a TI material. We tested four gelatin phantoms made with different concentrations of gelatin. Stress was applied by the weight of a water container centered on top of a plate on top of the phantom. A linear array transducer and a V-1 Verasonics system (Verasonics, Inc., Redmond, WA) were used to induce and measure shear waves in the phantoms. The shear wave motion was measured using a compound plane wave imaging technique and applying autocorrelation to the received in-phase/quadrature data. The shear wave velocity, c, was estimated using a Radon transform method. The transducer was mounted on a rotating stage so measurements were made every 10° over a range of 0-360°, where the stress is applied along 0-180° direction. The shear moduli were estimated. A TI model was fit to the data and the fractional anisotropy was evaluated. This approach can be used to explore many configurations of transverse isotropy with the same phantom, simply by applying stress to the tissue mimicking phantom.

Original languageEnglish (US)
Title of host publicationIEEE International Ultrasonics Symposium, IUS
PublisherIEEE Computer Society
Pages1834-1837
Number of pages4
ISBN (Print)9781479970490
DOIs
StatePublished - Oct 20 2014
Event2014 IEEE International Ultrasonics Symposium, IUS 2014 - Chicago, United States
Duration: Sep 3 2014Sep 6 2014

Other

Other2014 IEEE International Ultrasonics Symposium, IUS 2014
CountryUnited States
CityChicago
Period9/3/149/6/14

Fingerprint

isotropy
S waves
gelatins
organs
transducers
skeletal muscle
matrix materials
kidneys
linear arrays
radon
containers
quadratures
imaging techniques
embedding
autocorrelation
plane waves
mechanical properties
shear
anisotropy
fibers

Keywords

  • acoustoelasticity
  • shear wave
  • stress
  • transverse isotropy

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

Cite this

Urban, M. W., Kinnick, R. R., Zhang, X., & Greenleaf, J. F. (2014). Characterization of transverse isotropy in compressed tissue mimicking phantoms. In IEEE International Ultrasonics Symposium, IUS (pp. 1834-1837). [6932138] IEEE Computer Society. https://doi.org/10.1109/ULTSYM.2014.0455

Characterization of transverse isotropy in compressed tissue mimicking phantoms. / Urban, Matthew W; Kinnick, Randall R.; Zhang, Xiaoming; Greenleaf, James F.

IEEE International Ultrasonics Symposium, IUS. IEEE Computer Society, 2014. p. 1834-1837 6932138.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Urban, MW, Kinnick, RR, Zhang, X & Greenleaf, JF 2014, Characterization of transverse isotropy in compressed tissue mimicking phantoms. in IEEE International Ultrasonics Symposium, IUS., 6932138, IEEE Computer Society, pp. 1834-1837, 2014 IEEE International Ultrasonics Symposium, IUS 2014, Chicago, United States, 9/3/14. https://doi.org/10.1109/ULTSYM.2014.0455
Urban MW, Kinnick RR, Zhang X, Greenleaf JF. Characterization of transverse isotropy in compressed tissue mimicking phantoms. In IEEE International Ultrasonics Symposium, IUS. IEEE Computer Society. 2014. p. 1834-1837. 6932138 https://doi.org/10.1109/ULTSYM.2014.0455
Urban, Matthew W ; Kinnick, Randall R. ; Zhang, Xiaoming ; Greenleaf, James F. / Characterization of transverse isotropy in compressed tissue mimicking phantoms. IEEE International Ultrasonics Symposium, IUS. IEEE Computer Society, 2014. pp. 1834-1837
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