Characterization of porous injectable poly-(propylene fumarate)-based bone graft substitute

Choll W. Kim, Robert Talac, Lichun Lu, Michael J. Moore, Bradford L. Currier, Michael J. Yaszemski

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

The use of bone grafts for orthopedic applications have increased steadily over the past decade. With improvements in surgical technique, combined with an increasing aged population requiring orthopedic treatment, the need for bone grafts substitutes have also increased. To be useful clinically, the bone graft substitute must be biocompatible, bioabsorbable, and have convenient handling properties. In addition, it must possess a microarchitecture that allows cellular ingrowth and remodeling while simultaneously providing mechanical strength. Poly(propylene fumarate) (PPF) has been investigated as an injectable, biodegradable scaffold for orthopedic applications. Various methods to create a porous, interconnected polymer scaffold are available. The foaming technique is a convenient method to accomplish this task. Reactions between bicarbonate salts and weak acids generate CO2 gas, causing a bubbling reaction during the polymerization process. This technique allows the porosity of the scaffold to be modulated. Image analysis and mechanical testing of porous PPF fabricated using the foaming technique shows that a highly porous, interconnected scaffold can be produced. At ∼50% porosity, the scaffold has excellent handling properties, contains pore sizes ranging from 50 to 500 μm with an elastic modulus ranging from 20 to 40 MPa. The foaming technique provides an additional method by which clinically useful polymers can be fabricated for use in various bone tissue engineering applications.

Original languageEnglish (US)
Pages (from-to)1114-1119
Number of pages6
JournalJournal of Biomedical Materials Research - Part A
Volume85
Issue number4
DOIs
StatePublished - Jun 15 2008

Keywords

  • Biodegradable materials
  • Bone cement
  • Bone regeneration
  • Hydrogels
  • Synthetic polymers
  • Tissue engineering

ASJC Scopus subject areas

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys

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