Characterization of partially saturated poly(propylene fumarate) for orthopaedic application

Susan J. Peter; Michael J. Yaszemski; Laura J. Suggs; Richard G. Payne; Robert Langer; Wilson C. Hayes; Marilyn R. Unroe; Lawrence B. Alemany; Paul S. Engel; Antonios G. Mikos

doi:10.1163/156856297X00074

Characterization of partially saturated poly(propylene fumarate) for orthopaedic application

Susan J. Peter, Michael J. Yaszemski, Laura J. Suggs, Richard G. Payne, Robert Langer, Wilson C. Hayes, Marilyn R. Unroe, Lawrence B. Alemany, Paul S. Engel, Antonios G. Mikos

Orthopedic Surgery

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

A partially saturated linear polyester based on poly(propylene fumarate) (PPF) was synthesized for potential application in filling skeletal defects. The synthesis was carried out according to a two-step reaction scheme. Propylene glycol and fumaryl chloride were first combined to form an intermediate fumaric diester. The intermediate was then subjected to a transesterification to form the PPF-based polymer. This method allowed for production of a polymer with a number average molecular weight up to 1500 and a polydispersity index of 2.8 and below. The polymeric backbone structure was investigated through the use of FTIR and NMR. Kinetic studies of the transesterification allowed mapping of the molecular weight increase with reaction time. The final product was also characterized by thermal and solubility analysis.

Original language	English (US)
Pages (from-to)	893-904
Number of pages	12
Journal	Journal of Biomaterials Science, Polymer Edition
Volume	8
Issue number	11
DOIs	https://doi.org/10.1163/156856297X00074
State	Published - Jan 1 1997

Keywords

Bone cement
In situ polyrnerizable biomaterials
Poly(propylene fumarate)
Polymer characterization
Unsaturated polymers

ASJC Scopus subject areas

Biophysics
Bioengineering
Biomaterials
Biomedical Engineering

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10.1163/156856297X00074

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title = "Characterization of partially saturated poly(propylene fumarate) for orthopaedic application",

abstract = "A partially saturated linear polyester based on poly(propylene fumarate) (PPF) was synthesized for potential application in filling skeletal defects. The synthesis was carried out according to a two-step reaction scheme. Propylene glycol and fumaryl chloride were first combined to form an intermediate fumaric diester. The intermediate was then subjected to a transesterification to form the PPF-based polymer. This method allowed for production of a polymer with a number average molecular weight up to 1500 and a polydispersity index of 2.8 and below. The polymeric backbone structure was investigated through the use of FTIR and NMR. Kinetic studies of the transesterification allowed mapping of the molecular weight increase with reaction time. The final product was also characterized by thermal and solubility analysis.",

keywords = "Bone cement, In situ polyrnerizable biomaterials, Poly(propylene fumarate), Polymer characterization, Unsaturated polymers",

author = "Peter, {Susan J.} and Yaszemski, {Michael J.} and Suggs, {Laura J.} and Payne, {Richard G.} and Robert Langer and Hayes, {Wilson C.} and Unroe, {Marilyn R.} and Alemany, {Lawrence B.} and Engel, {Paul S.} and Mikos, {Antonios G.}",

note = "Funding Information: This work was performed through funding provided by the National Science Foun-dation, the Robert A. Welch Foundation (PSE), the National Institutes of Health (RO1-AR44381), and the T. N. Law Professorship at Rice University (AGM). S. J. Pe- ter and L. J. Suggs acknowledge financial support by the National Institutes of Health Biotechnology Training Grant 5T32GM08362. Our thanks go to Drs Jan Post and Shanmin Zhang at the University of Texas Medical Branch at Galveston for us access to the NMR facilities there to perform preliminary studies. We Dr. Terry Marriott for his help in acquiring the mass spectral data.",

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AU - Peter, Susan J.

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AU - Langer, Robert

AU - Hayes, Wilson C.

AU - Unroe, Marilyn R.

AU - Alemany, Lawrence B.

AU - Engel, Paul S.

AU - Mikos, Antonios G.

N1 - Funding Information: This work was performed through funding provided by the National Science Foun-dation, the Robert A. Welch Foundation (PSE), the National Institutes of Health (RO1-AR44381), and the T. N. Law Professorship at Rice University (AGM). S. J. Pe- ter and L. J. Suggs acknowledge financial support by the National Institutes of Health Biotechnology Training Grant 5T32GM08362. Our thanks go to Drs Jan Post and Shanmin Zhang at the University of Texas Medical Branch at Galveston for us access to the NMR facilities there to perform preliminary studies. We Dr. Terry Marriott for his help in acquiring the mass spectral data.

PY - 1997/1/1

Y1 - 1997/1/1

N2 - A partially saturated linear polyester based on poly(propylene fumarate) (PPF) was synthesized for potential application in filling skeletal defects. The synthesis was carried out according to a two-step reaction scheme. Propylene glycol and fumaryl chloride were first combined to form an intermediate fumaric diester. The intermediate was then subjected to a transesterification to form the PPF-based polymer. This method allowed for production of a polymer with a number average molecular weight up to 1500 and a polydispersity index of 2.8 and below. The polymeric backbone structure was investigated through the use of FTIR and NMR. Kinetic studies of the transesterification allowed mapping of the molecular weight increase with reaction time. The final product was also characterized by thermal and solubility analysis.

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Characterization of partially saturated poly(propylene fumarate) for orthopaedic application

Abstract

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