Characterization of material properties of soft solid thin layers with acoustic radiation force and wave propagation

Matthew W Urban, Ivan Z. Nenadic, Bo Qiang, Miguel Bernal, Shigao D Chen, James F Greenleaf

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Evaluation of tissue engineering constructs is performed by a series of different tests. In many cases it is important to match the mechanical properties of these constructs to those of native tissues. However, many mechanical testing methods are destructive in nature which increases cost for evaluation because of the need for additional samples reserved for these assessments. A wave propagation method is proposed for characterizing the shear elasticity of thin layers bounded by a rigid substrate and fluid-loading, similar to the configuration for many tissue engineering applications. An analytic wave propagation model was derived for this configuration and compared against finite element model simulations and numerical solutions from the software package Disperse. The results from the different models found very good agreement. Experiments were performed in tissue-mimicking gelatin phantoms with thicknesses of 1 and 4 mm and found that the wave propagation method could resolve the shear modulus with very good accuracy, no more than 4.10% error. This method could be used in tissue engineering applications to monitor tissue engineering construct maturation with a nondestructive wave propagation method to evaluate the shear modulus of a material.

Original languageEnglish (US)
Pages (from-to)2499-2507
Number of pages9
JournalJournal of the Acoustical Society of America
Volume138
Issue number4
DOIs
StatePublished - Oct 1 2015

Fingerprint

tissue engineering
sound waves
wave propagation
propagation
shear
evaluation
gelatins
configurations
elastic properties
mechanical properties
costs
computer programs
Radiation
Waves
Acoustics
Material Properties
Layer
fluids
Tissue Engineering
simulation

ASJC Scopus subject areas

  • Acoustics and Ultrasonics
  • Arts and Humanities (miscellaneous)

Cite this

Characterization of material properties of soft solid thin layers with acoustic radiation force and wave propagation. / Urban, Matthew W; Nenadic, Ivan Z.; Qiang, Bo; Bernal, Miguel; Chen, Shigao D; Greenleaf, James F.

In: Journal of the Acoustical Society of America, Vol. 138, No. 4, 01.10.2015, p. 2499-2507.

Research output: Contribution to journalArticle

@article{a0b42db999c94629815cd9bed8d14651,
title = "Characterization of material properties of soft solid thin layers with acoustic radiation force and wave propagation",
abstract = "Evaluation of tissue engineering constructs is performed by a series of different tests. In many cases it is important to match the mechanical properties of these constructs to those of native tissues. However, many mechanical testing methods are destructive in nature which increases cost for evaluation because of the need for additional samples reserved for these assessments. A wave propagation method is proposed for characterizing the shear elasticity of thin layers bounded by a rigid substrate and fluid-loading, similar to the configuration for many tissue engineering applications. An analytic wave propagation model was derived for this configuration and compared against finite element model simulations and numerical solutions from the software package Disperse. The results from the different models found very good agreement. Experiments were performed in tissue-mimicking gelatin phantoms with thicknesses of 1 and 4 mm and found that the wave propagation method could resolve the shear modulus with very good accuracy, no more than 4.10{\%} error. This method could be used in tissue engineering applications to monitor tissue engineering construct maturation with a nondestructive wave propagation method to evaluate the shear modulus of a material.",
author = "Urban, {Matthew W} and Nenadic, {Ivan Z.} and Bo Qiang and Miguel Bernal and Chen, {Shigao D} and Greenleaf, {James F}",
year = "2015",
month = "10",
day = "1",
doi = "10.1121/1.4932170",
language = "English (US)",
volume = "138",
pages = "2499--2507",
journal = "Journal of the Acoustical Society of America",
issn = "0001-4966",
publisher = "Acoustical Society of America",
number = "4",

}

TY - JOUR

T1 - Characterization of material properties of soft solid thin layers with acoustic radiation force and wave propagation

AU - Urban, Matthew W

AU - Nenadic, Ivan Z.

AU - Qiang, Bo

AU - Bernal, Miguel

AU - Chen, Shigao D

AU - Greenleaf, James F

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Evaluation of tissue engineering constructs is performed by a series of different tests. In many cases it is important to match the mechanical properties of these constructs to those of native tissues. However, many mechanical testing methods are destructive in nature which increases cost for evaluation because of the need for additional samples reserved for these assessments. A wave propagation method is proposed for characterizing the shear elasticity of thin layers bounded by a rigid substrate and fluid-loading, similar to the configuration for many tissue engineering applications. An analytic wave propagation model was derived for this configuration and compared against finite element model simulations and numerical solutions from the software package Disperse. The results from the different models found very good agreement. Experiments were performed in tissue-mimicking gelatin phantoms with thicknesses of 1 and 4 mm and found that the wave propagation method could resolve the shear modulus with very good accuracy, no more than 4.10% error. This method could be used in tissue engineering applications to monitor tissue engineering construct maturation with a nondestructive wave propagation method to evaluate the shear modulus of a material.

AB - Evaluation of tissue engineering constructs is performed by a series of different tests. In many cases it is important to match the mechanical properties of these constructs to those of native tissues. However, many mechanical testing methods are destructive in nature which increases cost for evaluation because of the need for additional samples reserved for these assessments. A wave propagation method is proposed for characterizing the shear elasticity of thin layers bounded by a rigid substrate and fluid-loading, similar to the configuration for many tissue engineering applications. An analytic wave propagation model was derived for this configuration and compared against finite element model simulations and numerical solutions from the software package Disperse. The results from the different models found very good agreement. Experiments were performed in tissue-mimicking gelatin phantoms with thicknesses of 1 and 4 mm and found that the wave propagation method could resolve the shear modulus with very good accuracy, no more than 4.10% error. This method could be used in tissue engineering applications to monitor tissue engineering construct maturation with a nondestructive wave propagation method to evaluate the shear modulus of a material.

UR - http://www.scopus.com/inward/record.url?scp=84946065917&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84946065917&partnerID=8YFLogxK

U2 - 10.1121/1.4932170

DO - 10.1121/1.4932170

M3 - Article

C2 - 26520332

AN - SCOPUS:84946065917

VL - 138

SP - 2499

EP - 2507

JO - Journal of the Acoustical Society of America

JF - Journal of the Acoustical Society of America

SN - 0001-4966

IS - 4

ER -